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Titolo:
SELECTIVE EXPRESSION OF MESSENGER-RNA CODING FOR THE TRUNCATED FORM OF ERYTHROPOIETIN RECEPTOR IN HEMATOPOIETIC-CELLS AND ITS DECREASE IN PATIENTS WITH POLYCYTHEMIA-VERA
Autore:
CHIBA S; TAKAHASHI T; TAKESHITA K; MINOWADA J; YAZAKI Y; RUDDLE FH; HIRAI H;
Indirizzi:
UNIV TOKYO,FAC MED,DEPT INTERNAL MED 3,BUNKYO KU,7-3-1 HONGO TOKYO 113 JAPAN UNIV TOKYO,FAC MED,DEPT INTERNAL MED 3,BUNKYO KU TOKYO 113 JAPAN UNIV TOKYO,FAC MED,DEPT CELL THERAPY & TRANSPLANTAT MED,BUNKYO KU TOKYO 113 JAPAN YALE UNIV,DEPT BIOL NEW HAVEN CT 00000 YALE UNIV,DEPT HUMAN GENET NEW HAVEN CT 06510 YALE UNIV,DEPT MED NEW HAVEN CT 06520 NYU MED CTR,DEPT INTERNAL MED,DIV HEMATOL NEW YORK NY 10016 HAYASHIBARA BIOCHEM RES LABS,FUJISAKI CELL CTR OKAYAMA JAPAN
Titolo Testata:
Blood
fascicolo: 1, volume: 90, anno: 1997,
pagine: 97 - 104
SICI:
0006-4971(1997)90:1<97:SEOMCF>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECOMBINANT-HUMAN-ERYTHROPOIETIN; COLONY-STIMULATING FACTOR; GENE; LINE; ESTABLISHMENT; PROGENITORS; ACTIVATION; GENERATION; LEUKEMIA; PROTEINS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
S. Chiba et al., "SELECTIVE EXPRESSION OF MESSENGER-RNA CODING FOR THE TRUNCATED FORM OF ERYTHROPOIETIN RECEPTOR IN HEMATOPOIETIC-CELLS AND ITS DECREASE IN PATIENTS WITH POLYCYTHEMIA-VERA", Blood, 90(1), 1997, pp. 97-104

Abstract

The mRNA encoding full-length erythropoietin (EPO) receptor (EPOR-F) comprises exons [through VIII. Another membrane-bound EPOR (EPOR-T) isoform has a truncated cytoplasmic region and is encoded by the mRNA containing unspliced intron VII (EPOR-T mRNA), EPOR-T is believed to have a dominantly negative function against EPOR-F. We show that EPOR-T mRNA is markedly decreased in the blood cells of patients with polycythemia vera (PV), We also show that EPOR-T mRNA is not detected in erythroid/megakaryocytic leukemia cell lines, but is expressed in nonerythroid/nonmegakaryocytic lines, suggesting the presence of a cell type-specific system by which intron VII of the EPOR transcript is spliced. Deregulation of this splicing system in early hematopoietic progenitorspossibly explains the profound decrease in EPOR-T mRNA and consequentpathophysiology of PV. (C) 1997 by The American Society of Hematology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 16:02:09