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Titolo:
Barbiturates inhibit K+-evoked noradrenaline and dopamine release from ratstriatal slices - involvement of voltage sensitive Ca2+ channels
Autore:
Hirota, K; Kudo, M; Kudo, T; Kitayama, M; Kushikata, T; Lambert, DG; Matsuki, A;
Indirizzi:
Hirosaki Univ, Sch Med, Dept Anesthesiol, Hirosaki, Aomori 0368563, Japan Hirosaki Univ Hirosaki Aomori Japan 0368563 rosaki, Aomori 0368563, Japan Leicester Royal Infirm, Dept Anaesthesia & Pain Management, Leicester LE1 5WW, Leics, England Leicester Royal Infirm Leicester Leics England LE1 5WWWW, Leics, England
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 3, volume: 291, anno: 2000,
pagine: 175 - 178
SICI:
0304-3940(20000922)291:3<175:BIKNAD>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRAIN-SLICES; GABA(A) RECEPTORS; CALCIUM CHANNELS; ION CHANNELS; CURRENTS; THIOPENTONE; ANESTHESIA; GLUTAMATE; NEURONS; CELLS;
Keywords:
barbiturates; thiopental; pentobarbital; phenobarbital; barbituric acid; noradrenaline release; dopamine release; Ca2+ channel;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Hirota, K Hirosaki Univ, Sch Med, Dept Anesthesiol, Hirosaki, Aomori 0368563, Japan Hirosaki Univ Hirosaki Aomori Japan 0368563 mori 0368563, Japan
Citazione:
K. Hirota et al., "Barbiturates inhibit K+-evoked noradrenaline and dopamine release from ratstriatal slices - involvement of voltage sensitive Ca2+ channels", NEUROSCI L, 291(3), 2000, pp. 175-178

Abstract

The cellular target site(s) for anaesthetic action remain unclear. In rat striatal slices we have previously demonstrated that K+-evoked noradrenaline (NA) and dopamine (DA) release is mediated predominantly via P/Q-type voltage sensitive Ca2+ channels (VSCC). Using this model of Ca2+ dependent transmitter release we have evaluated the effects of anaesthetic and non-anaesthetic barbiturates. Rat brain striatal slices were incubated in the absence and presence of barbiturate for 10 min at 37 degrees C. The slices were then incubated for 6 min with 40 mM KCl. All anaesthetic barbiturates produced a concentration-dependent inhibition of K+-evoked NA and DA release. Non-anaesthetic barbiturate, barbituric acid was ineffective. The pIC(50) for NA and DA release (thiopental: 4.90 +/- 0.13 and 5.00 +/- 0.10, pentobarbital: 4.39 +/- 0.07 and 4.43 +/- 0.14, phenobarbital: 3.85 +/- 0.08 and 3.59 /- 0.10, respectively) correlated with lipid solubility (NA: r(2) = 0.999,DA: r(2) = 0.987). We therefore suggest that barbiturates inhibit catecholamine release via an interaction with P/Q VSCC further implicating this channel in anaesthetic action. (C) 2000 Elsevier Science ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/05/20 alle ore 14:14:36