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Titolo:
Non-serotonergic midbrain neurons are involved in picrotoxin-induced analgesia. An immunohistochemical study in the rat
Autore:
Koyama, N; Nishio, T; Yokota, T;
Indirizzi:
Shiga Univ Med Sci, Dept Physiol, Otsu, Shiga 5202192, Japan Shiga Univ Med Sci Otsu Shiga Japan 5202192 l, Otsu, Shiga 5202192, Japan Kyoto Univ, Fac Med, Dept Integrat Brain Sci, Kyoto 6068501, Japan Kyoto Univ Kyoto Japan 6068501 Integrat Brain Sci, Kyoto 6068501, Japan
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 3, volume: 291, anno: 2000,
pagine: 147 - 150
SICI:
0304-3940(20000922)291:3<147:NMNAII>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
DORSAL RAPHE; PAIN MODULATION; NUCLEUS; EXPRESSION; CAT; FOS; ANTINOCICEPTION;
Keywords:
periaqueductal gray; nucleus raphe dorsalis; Edinger-Westphal nucleus; c-Fos; 5HT; picrotoxin; descending antinociceptive system;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Koyama, N Shiga Univ Med Sci, Dept Physiol, Otsu, Shiga 5202192, Japan Shiga Univ Med Sci Otsu Shiga Japan 5202192 higa 5202192, Japan
Citazione:
N. Koyama et al., "Non-serotonergic midbrain neurons are involved in picrotoxin-induced analgesia. An immunohistochemical study in the rat", NEUROSCI L, 291(3), 2000, pp. 147-150

Abstract

Intravenous picrotoxin inhibits spinal nociceptive neurons through disinhibitory activation of neurons in the periaqueductal gray (PAG) and nucleus raphe dorsalis (NRD), where the descending antinociceptive system arises. Wefound Fos-like immunoreactivity in PAG/NRD neurons after intravenous injection of picrotoxin. This distribution of c-Fos expression is consistent with a role of PAG/NRD for antinociception; neurons with intense Fos-like immunoreactivity was also clustered in the Edinger-Westphal nucleus (EW). Double fluorescence immunohistochemistry for c-Fos and serotonin revealed that PAG/NRD/EW neurons expressing c-Fos were non-serotonergic, These data suggest that nonserotonergic PAG/NRD/EW neurons are involved in the picrotoxin-induced analgesia. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 19:29:58