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Titolo:
Blockade by pertussis toxin of the opioid effect on guinea pig ileum. Contractility and electrophysiological neuronal recording
Autore:
Abalo, R; Pascual, D; Goicoechea, C; Martin, MI;
Indirizzi:
Univ Complutense Madrid, Fac Med, Dept Farmacol, E-28040 Madrid, Spain Univ Complutense Madrid Madrid Spain E-28040 acol, E-28040 Madrid, Spain
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 3, volume: 291, anno: 2000,
pagine: 131 - 134
SICI:
0304-3940(20000922)291:3<131:BBPTOT>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
ILEAL MYENTERIC PLEXUS; G-PROTEINS; INHIBITION; CHANNELS; RECEPTOR; RELEASE;
Keywords:
opioid; guinea pig ileum; neuronal electrophysiological recording; S-type neurone; myenteric plexus; pertussis toxin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Martin, MI Univ Complutense Madrid, Fac Med, Dept Farmacol, E-28040 Madrid, Spain Univ Complutense Madrid Madrid Spain E-28040 40 Madrid, Spain
Citazione:
R. Abalo et al., "Blockade by pertussis toxin of the opioid effect on guinea pig ileum. Contractility and electrophysiological neuronal recording", NEUROSCI L, 291(3), 2000, pp. 131-134

Abstract

The aim of the present study was to analyse the correlation between functional and electrophysiological effects of the opioids in guinea pig ileum. Preparations of guinea pig ileum myenteric plexus-longitudinal muscle stripswere used to compare the effect of two opioids, morphine (a mu-agonist) and U-50,488H (a kappa-agonist) on the electrically-induced contractile response and the excitatory postsynaptic potentials exhibited by the myenteric neurones when the internodal strands are electrically stimulated. Both opioids dose-dependently inhibited the contractile responses and the fast excitatory postsynaptic potentials (fEPSPs) in S neurones but did not modify the amplitude of the slow postsynaptic potentials. Pertussis toxin pretreatmentwas able to antagonise the effects of both morphine and U-50,448H. From our results it can be suggested that the effect of the opioids on guinea pig ileum involves the inhibition of neuronal fEPSPs. (C) 2000 Elsevier ScienceIreland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 08:15:16