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Titolo:
Specific binding and laterality of human extrastriatal dopamine D-2/D-3 receptors in late onset type 1 alcoholic patients
Autore:
Kuikka, JT; Repo, E; Bergstrom, KA; Tupala, E; Tiihonen, J;
Indirizzi:
Kuopio Univ Hosp, Dept Clin Physiol, FIN-70210 Kuopio, Finland Kuopio UnivHosp Kuopio Finland FIN-70210 iol, FIN-70210 Kuopio, Finland Univ Kuopio, Dept Forens Psychiat, Niuvanniemi Hosp, FIN-40240 Kuopio, Finland Univ Kuopio Kuopio Finland FIN-40240 emi Hosp, FIN-40240 Kuopio, Finland
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 1, volume: 292, anno: 2000,
pagine: 57 - 59
SICI:
0304-3940(20000929)292:1<57:SBALOH>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN BRAIN; I-123 EPIDEPRIDE; TRANSPORTER; WITHDRAWAL; DENSITIES; ETHANOL;
Keywords:
alcoholism; dopamine; extrastriatal; heterogeneity; laterality; single-photon emission tomography;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Kuikka, JT Kuopio Univ Hosp, Dept Clin Physiol, FIN-70210 Kuopio, Finland Kuopio Univ Hosp Kuopio Finland FIN-70210 210 Kuopio, Finland
Citazione:
J.T. Kuikka et al., "Specific binding and laterality of human extrastriatal dopamine D-2/D-3 receptors in late onset type 1 alcoholic patients", NEUROSCI L, 292(1), 2000, pp. 57-59

Abstract

Late onset type 1 alcoholism has been suggested to be associated with decreased dopaminergic transmission. Our hypothesis was that late onset type 1 alcoholics have also abnormal extrastriatal dopamine D-2/D-3 receptor distribution. We performed binding, heterogeneity and laterality analysis of extrastriatal and striatal dopamine D-2/D-3 receptors in nine late onset male alcoholics and in 12 age-matched healthy males. A radioligand, [I-123]epidepride was used in high resolution single-photon emission tomography (SPET). Specific binding of epidepride in the left temporal pole was significantly(P < 0.05) lower in type 1 alcoholics (0.74 +/- 0.14 ml/ml) than in controls (0.89 +/- 0.14 ml/ml). In alcoholics, there was no normal left-to-right asymmetry of the temporal cortical heterogeneity of epidepride distributionobserved in control males (0.89 +/- 0.19 vs. 1.10 +/- 0.19; P < 0.05). Theresults suggest that the specific binding of dopamine D-2/D-3 receptors inlate type 1 alcoholics is decreased and its laterality in the temporal brain is altered from normal. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 10:47:25