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Titolo:
Postsynaptic origin of N-methyl-D-aspartate-induced slow currents in substantia gelatinosa neurons: an in vitro voltage-clamp study in adult rat
Autore:
Yang, K; Li, YO;
Indirizzi:
Fourth Mil Med Univ, Dept Anat, Xian 710032, Peoples R China Fourth Mil Med Univ Xian Peoples R China 710032 710032, Peoples R China Fourth Mil Med Univ, KK Leung Brain Res Ctr, Xian 710032, Peoples R China Fourth Mil Med Univ Xian Peoples R China 710032 710032, Peoples R China
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 1, volume: 292, anno: 2000,
pagine: 21 - 24
SICI:
0304-3940(20000929)292:1<21:POONSC>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPINAL DORSAL HORN; PRIMARY AFFERENT SYNAPSES; SYNAPTIC TRANSMISSION; CORD;
Keywords:
substantia gelatinosa; N-methyl-D-aspartate receptor; excitatory postsynaptic currents; spinal cord; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Li, YO Fourth Mil Med Univ, Dept Anat, Xian 710032, Peoples R China FourthMil Med Univ Xian Peoples R China 710032 , Peoples R China
Citazione:
K. Yang e Y.O. Li, "Postsynaptic origin of N-methyl-D-aspartate-induced slow currents in substantia gelatinosa neurons: an in vitro voltage-clamp study in adult rat", NEUROSCI L, 292(1), 2000, pp. 21-24

Abstract

We investigated whether N-methyl-D-aspartate (NMDA)-induced slow current in substantia gelatinosa (SG) neurons might be of presynaptic or postsynaptic origin,Whole-cell voltage-clamp recordings were made from adult rat spinal cord slices to examine the effect of NMDA receptor upon miniature excitatory postsynaptic currents (mEPSCs) in SG neurons. At a holding potential of-70 mV, bath application of NMDA(10 mu M, 30 s), an NMDA receptor agonist,affected neither the frequency nor the mean amplitude of mEPSCs, while NMDA induced a slow excitatory membrane current which persisted in the presence of tetrodotoxin. On the other hand, AP-5 tan NMDA receptor antagonist) had no noticeable effects on mEPSCs in the SG neurons tested, while it markedly depressed the NMDA-induced slow currents. The NMDA-induced slow currentsvaried with the changing of holding potentials (from -70 to 0 mV). The results suggested that the NM DA-induced slow currents in SG neurons were of postsynaptic origin. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 04:43:55