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Titolo:
Exogenous brain-derived neurotrophic factor regulates the synaptic composition of axonally lesioned and normal adult rat motoneurons
Autore:
Novikov, LN; Novikova, LN; Holmberg, P; Kellerth, JO;
Indirizzi:
Umea Univ, Sect Anat, Dept Integrat Med Biol, S-90187 Umea, Sweden Umea Univ Umea Sweden S-90187 pt Integrat Med Biol, S-90187 Umea, Sweden
Titolo Testata:
NEUROSCIENCE
fascicolo: 1, volume: 100, anno: 2000,
pagine: 171 - 181
SICI:
0306-4522(2000)100:1<171:EBNFRT>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPINAL ALPHA-MOTONEURONS; MOTOR-NEURON DEGENERATION; PERIPHERAL-NERVE INJURY; SCIATIC-NERVE; INHIBITORY SYNAPSES; LUMBAR MOTONEURONS; GAMMA-MOTONEURONS; HYPOGLOSSAL NERVE; MESSENGER-RNA; CELL-BODIES;
Keywords:
avulsion; neurotrophic factors; spinal cord; synapse; synaptophysin; synaptic plasticity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
69
Recensione:
Indirizzi per estratti:
Indirizzo: Kellerth, JO Umea Univ, Sect Anat, Dept Integrat Med Biol, S-90187 Umea, Sweden Umea Univ Umea Sweden S-90187 ed Biol, S-90187 Umea, Sweden
Citazione:
L.N. Novikov et al., "Exogenous brain-derived neurotrophic factor regulates the synaptic composition of axonally lesioned and normal adult rat motoneurons", NEUROSCIENC, 100(1), 2000, pp. 171-181

Abstract

Brain-derived neurotrophic factor has previously been shown to promote survival and axonal regeneration in injured spinal motoneurons and, also, to modulate synaptic transmission and regulate the density of synaptic innervation in a variety of neurons. The present light and electron microscopic study demonstrates synaptotrophic effects of exogenously applied brain-derivedneurotrophic factor on the synaptic composition of both normal and axonally lesioned adult rat spinal motoneurons. After L5-L6 ventral root avulsion,a massive loss of all types of boutons occurred on the somata of the lesioned motoneurons which persisted for at least 12 weeks postoperatively. We found that (i) intrathecal infusion of brain-derived neurotrophic factor during the first postoperative week did not prevent the synaptic detachment and activation of glial cells; (ii) prolonged treatment for four weeks restored synaptic covering and significantly reduced microglial reaction; (iii) the synaptotrophic effect remained significant for at least eight weeks after cessation of the treatment; (iv) brain-derived neurotrophic factor mainlysupported type boutons with presumably inhibitory function, while it had little effect on S-type boutons associated with excitatory action; and (v) in normal unlesioned motoneurons, four weeks of treatment with brain-derivedneurotrophic factor induced sprouting of F-type boutons, a loss of S-type boutons and motoneuron atrophy. The present data show that exogenous neurotrophins not only help to restore synaptic circuitry in axonally injured motoneurons, but also strongly influence the synaptic composition in normal motoneurons. (C) 2000 IBRO. Published by Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 18:19:39