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Titolo:
Comparative immunohistochemical distributions of carboxy terminus epitopesfrom the mu-opioid receptor splice variants MOR-1D, MOR-1 and MOR-1C in the mouse and rat CNS
Autore:
Abbadie, C; Pan, YX; Drake, CT; Pasternak, GW;
Indirizzi:
Mem Sloan Kettering Canc Ctr, Lab Mol Neuropharmacol, New York, NY 10021 USA Mem Sloan Kettering Canc Ctr New York NY USA 10021 New York, NY 10021 USA Cornell Univ, Weill Med Coll, Dept Neurol & Neurosci, New York, NY 10021 USA Cornell Univ New York NY USA 10021 rol & Neurosci, New York, NY 10021 USA
Titolo Testata:
NEUROSCIENCE
fascicolo: 1, volume: 100, anno: 2000,
pagine: 141 - 153
SICI:
0306-4522(2000)100:1<141:CIDOCT>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUBSTANTIA-GELATINOSA ROLANDI; CENTRAL-NERVOUS-SYSTEM; SPINAL-CORD; OPIATE-RECEPTOR; DORSAL HORN; ANTISENSE OLIGODEOXYNUCLEOTIDES; ULTRASTRUCTURAL-LOCALIZATION; HIPPOCAMPAL-FORMATION; SUPERFICIAL LAYERS; PROMOTER REGION;
Keywords:
CNS; immunohistochemistry; mu-opioid receptor; mouse; splice variant;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
62
Recensione:
Indirizzi per estratti:
Indirizzo: Pasternak, GW Mem Sloan Kettering Canc Ctr, Lab Mol Neuropharmacol, 1275 York Ave, New York, NY 10021 USA Mem Sloan Kettering Canc Ctr 1275 York Ave New York NY USA 10021
Citazione:
C. Abbadie et al., "Comparative immunohistochemical distributions of carboxy terminus epitopesfrom the mu-opioid receptor splice variants MOR-1D, MOR-1 and MOR-1C in the mouse and rat CNS", NEUROSCIENC, 100(1), 2000, pp. 141-153

Abstract

The present study examined immunohistochemically the CNS distributions of a splice variant of the mu-opioid receptor, MOR-1D, in both rats and mice. In MOR-1D, exon 4 of MOR-1 is replaced by two additional exons that code for seven amino acids. Using rabbit antisera, we compared immunohistochemically the regional distribution of a C-terminal epitope of MOR-1D to that of aC-terminal epitope from MOR-1 and a C-terminal epitope from another splicevariant, MOR-1C The general distribution of MOR-1D-like immunoreactivity was similar in both mouse and rat. MOR-1D-like immunoreactivity was seen in the dentate gyrus and in the mossy fibers of the hippocampal formation, thenucleus of the solitary tract and the area postrema, the inferior olivary nucleus, the nucleus ambiguous, the spinal trigeminal nucleus and the spinal cord. MOR-1D-like immunoreactivity was not observed in some regions containing dense MOR-1-like immunoreactivity, such as the striatum or the locus coeruleus. In regions containing MOR-1, MOR-1C and MOR-1D, the pattern of each variant was unique. MOR-1D and MOR-1C are splice variants of the cloned mu-opioid receptor MOR-1. Although they differ only at the tip of the carboxy terminus, they showmarked differences in their regional distributions, as determined immunohistochemically by epitopes in their unique carboxy termini. Since the splicevariants are derived from the same gene, these differences in regional distribution imply region-specific messenger RNA processing. (C) 2000 IBRO. Published by Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 11:00:03