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Titolo:
In vitro growth of human primordial follicles from frozen-banked ovarian tissue
Autore:
Picton, HM; Gosden, RG;
Indirizzi:
Univ Leeds, Sch Med, Acad Unit Paediat Obstet & Gynaecol, Leeds, W Yorkshire, England Univ Leeds Leeds W Yorkshire England naecol, Leeds, W Yorkshire, England McGill Univ, Sch Med, Dept Obstet & Gynaecol, Montreal, PQ, Canada McGill Univ Montreal PQ Canada t Obstet & Gynaecol, Montreal, PQ, Canada
Titolo Testata:
MOLECULAR AND CELLULAR ENDOCRINOLOGY
fascicolo: 1, volume: 166, anno: 2000,
pagine: 27 - 35
SICI:
0303-7207(20000815)166:1<27:IVGOHP>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM CULTURE; IN-VITRO; STIMULATING-HORMONE; GRANULOSA-CELLS; HUMAN OOCYTES; DEVELOPMENTAL COMPETENCE; MOUSE OOCYTES; INVITRO FERTILIZATION; ESTRADIOL PRODUCTION; PREANTRAL FOLLICLES;
Keywords:
follicle growth; granulosa cell; in vitro; oocyte; primordial follicle;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
61
Recensione:
Indirizzi per estratti:
Indirizzo: Picton, HM Dept Obstet & Gynaecol, Reprod Biol Grp, D Floor,Clarendon WingLGI,Belmont Grove, Leeds LS2 9NS, W Yorkshire, England Dept Obstet & Gynaecol D Floor,Clarendon Wing LGI,Belmont Grove Leeds W Yorkshire England LS2 9NS
Citazione:
H.M. Picton e R.G. Gosden, "In vitro growth of human primordial follicles from frozen-banked ovarian tissue", MOL C ENDOC, 166(1), 2000, pp. 27-35

Abstract

The rarity of human oocytes frequently limits the success of assisted reproductive technology and delays research progress. Development of technologies to grow mature oocytes from the more abundant small follicles, perhaps after long-term storage at low temperatures, is a theoretically attractive solution to both problems. The length of the follicular growth span from theprimordial to Graafian stage and changes in the trophic requirements of the cells, cellular interactions, morphogenesis and the sheer increase in bulk as the antrum forms are major challenges for cell culture technology. Even so, much progress has been made with animal follicles, and has begun withhuman tissue. A multi-step procedure, which reflects these changes, is perhaps the most likely to succeed. At present, the best strategy appears to be to initiate follicle growth in situ and isolate the follicles or granulosa-oocyte complexes once they have progressed to preantral stages. The finalstep is to mature the oocytes within their cumulus cells. The prospects ofsucceeding at each stage, and producing a fertile gamete at the end, are likely to be greater by preserving cellular interactions and the phenotype of follicle cells as these provide the physiological environment in which oocytes develop. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 07:25:01