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Titolo:
Antiplatelet and anticancer isothiocyanates in Japanese domestic horseradish, Wasabi
Autore:
Morimitsu, Y; Hayashi, K; Nakagawa, Y; Fujii, H; Horio, F; Uchida, K; Osawa, T;
Indirizzi:
Nagoya Univ, Grad Sch Bioagr Sci, Lab Food & Biodynam, Nagoya, Aichi 4648601, Japan Nagoya Univ Nagoya Aichi Japan 4648601 ynam, Nagoya, Aichi 4648601, Japan Nagoya Univ, Grad Sch Bioagr Sci, Div Biomodeling, Nagoya, Aichi 4648601, Japan Nagoya Univ Nagoya Aichi Japan 4648601 ling, Nagoya, Aichi 4648601, Japan
Titolo Testata:
MECHANISMS OF AGEING AND DEVELOPMENT
fascicolo: 2-3, volume: 116, anno: 2000,
pagine: 125 - 134
SICI:
0047-6374(20000731)116:2-3<125:AAAIIJ>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUTATHIONE-S-TRANSFERASE; PLATELET-AGGREGATION; METABOLIZING-ENZYMES; LIPID-PEROXIDATION; INDUCTION; BROCCOLI; LIVER; INDUCERS; SPROUTS; CABBAGE;
Keywords:
isothiocyanate; wasabi; platelet aggregation; phase II enzyme; glutathione S-transferase; cancer chemoprevention;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Morimitsu, Y Ochanomizu Univ, Dept Nutr & Food Sci, Food Chem Lab, Bunkyo Ku, Otsuka 2-1-1, Tokyo 1128610, Japan Ochanomizu Univ Otsuka 2-1-1 Tokyo Japan 1128610 8610, Japan
Citazione:
Y. Morimitsu et al., "Antiplatelet and anticancer isothiocyanates in Japanese domestic horseradish, Wasabi", MECH AGE D, 116(2-3), 2000, pp. 125-134

Abstract

6-Methylsulfinylhexyl isothiocyanate (MS-ITC) was isolated from wasabi ( Wasabia japonica, Japanese domestic horseradish) as a potential inhibitor ofhuman platelet aggregation in vitro through our extensive screening of vegetables and fruits. In the course of an another screening for the inductionof glutathione S-transferase (GST) activity in RL34 cells, MS-ITC was inadvertently isolated from wasabi as a potential inducer of GST. MS-ITC administered to rats or mice also showed both activities in vivo. As a result from elucidation of the platelet aggregation inhibition and the GST induction mechanisms of MS-ITC, the isothiocyanate moiety of MS-ITC plays an important role for antiplatelet and anticancer activities because of its high reactivity with sulfhydryl (RSH) groups in biomolecules (GSH, cysteine residue in a certain protein, etc.). (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 12:24:08