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Titolo:
Effect of aging on the modulation of macrophage functions by neuropeptides
Autore:
De la Fuente, M; Medina, S; Del Rio, M; Ferrandez, MD; Hernanz, A;
Indirizzi:
Univ Complutense, Fac Biol, Dept Anim Physiol, E-28040 Madrid, Spain Univ Complutense Madrid Spain E-28040 nim Physiol, E-28040 Madrid, Spain Hosp La Paz, Dept Biochem, Madrid, Spain Hosp La Paz Madrid SpainHosp La Paz, Dept Biochem, Madrid, Spain
Titolo Testata:
LIFE SCIENCES
fascicolo: 17, volume: 67, anno: 2000,
pagine: 2125 - 2135
SICI:
0024-3205(20000915)67:17<2125:EOAOTM>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
SULFATED CHOLECYSTOKININ-OCTAPEPTIDE; GASTRIN-RELEASING PEPTIDE; MURINE PERITONEAL-MACROPHAGES; NERVOUS-SYSTEM; ADHERENCE; AGE; CELLS; CHEMOTAXIS; STRESS; LYMPHOCYTES;
Keywords:
macrophages; CCK-8s; GRP; NPY; mice; aging;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: De la Fuente, M Univ Complutense, Fac Ciencias Biol, Dept Biol Anim FisiolAnim 2, Av Complutense S-N, E-28040 Madrid, Spain Univ Complutense Av Complutense S-N Madrid Spain E-28040
Citazione:
M. De la Fuente et al., "Effect of aging on the modulation of macrophage functions by neuropeptides", LIFE SCI, 67(17), 2000, pp. 2125-2135

Abstract

The existence of a functional connection between the nervous and the immune system is supported by increasing recent evidence. In previous work we have shown that peptides from the nervous system, such as gastrin-releasing peptide (GRP), neuropeptide Y (NPY) and sulfated cholecystokinin octapeptide(CCK-8s), have modulatory effects on the immune functions in adult animals. Since the immunodepression found in aging organisms may be related to changes in the neuroimmune network, the aim of the present work was to study the changes with aging in the effect of CCK-8s, GRP and NPY on peritoneal macrophage functions (adherence to tissues, mobility, ingestion of foreign particles and superoxide anion production) from BALB/c mice of three different ages: adult (24+/-2 weeks old), mature (50+/-2 weeks old) and old (72+/-2weeks old). The results show that the increase in adherence capacity produced by neuropeptides in cells from adult and mature animals disappears in old mice. The stimulatory effect of GRP and NPY on mobility, ingestion and superoxide production in macrophages from adult mice disappears (GRP) or changes to inhibition (NPY) in cells from old animals. The decrease of these functions caused by CCK-8s in adult or mature animals continues in old mice. These data suggest that the modulation by neuropeptides of the macrophage function changes with the age of animals, (C) 2000 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 21:46:47