Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Neuromuscular junction
Autore:
Bigalke, H;
Indirizzi:
Med Hsch Hannover, Inst Toxicol, D-30625 Hannover, Germany Med Hsch Hannover Hannover Germany D-30625 ol, D-30625 Hannover, Germany
Titolo Testata:
KLINISCHE NEUROPHYSIOLOGIE
fascicolo: 3, volume: 31, anno: 2000,
pagine: 115 - 121
SICI:
1434-0275(200009)31:3<115:NJ>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
GER
Soggetto:
RETROGRADE AXONAL-TRANSPORT; BOTULINUM-A NEUROTOXINS; TETANUS TOXIN; CLOSTRIDIAL NEUROTOXINS; CHROMAFFIN CELLS; SYNAPTIC VESICLES; MEMBRANE-FUSION; PROTEIN-RECEPTOR; B NEUROTOXIN; RAT-BRAIN;
Keywords:
exozytose; endozytose; clostridientoxin; botulinumtoxin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Bigalke, H Med Hsch Hannover, Inst Toxicol, D-30625 Hannover, Germany Med Hsch Hannover Hannover Germany D-30625 Hannover, Germany
Citazione:
H. Bigalke, "Neuromuscular junction", KLIN NEUROP, 31(3), 2000, pp. 115-121

Abstract

The neuromuscular junction connects nervous tissue and striated muscles. It is a highly specialized structure which, following a sequence of steps, converts the incoming electric stimulus to a chemical signal, the release oftransmitter. The muscle responds to the signal by contraction. The cascadeof events leading to liberation of transmitter has been classified. It starts with depolarisation of the presynaptic terminal due to the opening of Na+ channels. The depolarisation triggers a Ca++ influx. Ca++ ions release abreak that prevents vesicles from fusion with the plasma membrane. The Ca+-induced fusion is a highly conserved process occurring in all cells with secretory capabilities including yeast. A set of proteins is involved in fusion which are the targets for clostridial neurotoxins. These toxins act preferentially on nerve cells because only nerve cells express receptors for the toxins. Following internalisation clostridial neurotoxins cleave the proteins at distinct sites. Since these proteins are necessary for fusion to occur, the conversion of the electric stimulus to the chemical signal is interrupted and the release of transmitter is inhibited. This leads to paralysis of striated muscles. When the toxins are degraded, fusion recovers without leaving any damage to the nerve cell.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 10:19:37