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Titolo:
Serum C-peptide, insulin-like growth factor (IGF)-I, IGF-binding proteins,and colorectal cancer risk in women
Autore:
Kaaks, R; Toniolo, P; Akhmedkhanov, A; Lukanova, A; Biessy, C; Dechaud, H; Rinaldi, S; Zeleniuch-Jacquotte, A; Shore, RE; Riboli, E;
Indirizzi:
Int Agcy Res Canc, F-69372 Lyon 08, France Int Agcy Res Canc Lyon France08 Agcy Res Canc, F-69372 Lyon 08, France NYU, Sch Med, Dept Obstet & Gynecol, New York, NY USA NYU New York NY USA YU, Sch Med, Dept Obstet & Gynecol, New York, NY USA NYU, Sch Med, Dept Environm Med, New York, NY USA NYU New York NY USANYU, Sch Med, Dept Environm Med, New York, NY USA Hop Antiquaille, Cent Lab Biochem, Lyon, France Hop Antiquaille Lyon France Antiquaille, Cent Lab Biochem, Lyon, France
Titolo Testata:
JOURNAL OF THE NATIONAL CANCER INSTITUTE
fascicolo: 19, volume: 92, anno: 2000,
pagine: 1592 - 1600
Fonte:
ISI
Lingua:
ENG
Soggetto:
DIABETES-MELLITUS; COLON-CANCER; FACTOR-I; NUTRITIONAL REGULATION; CALORIC RESTRICTION; PHYSICAL-ACTIVITY; PLASMA-GLUCOSE; FACTOR AXIS; CELL-LINE; FOLLOW-UP;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Kaaks, R Int Agcy Res Canc, 150 Cours Albert Thomas, F-69372 Lyon 08, France Int Agcy Res Canc 150 Cours Albert Thomas Lyon France 08 France
Citazione:
R. Kaaks et al., "Serum C-peptide, insulin-like growth factor (IGF)-I, IGF-binding proteins,and colorectal cancer risk in women", J NAT CANC, 92(19), 2000, pp. 1592-1600

Abstract

Background: Leading a Western lifestyle, being overweight, and being sedentary are associated with an increased risk of colorectal cancer. Recent theories propose that the effects of these risk factors may be mediated by increases in circulating insulin levels and in the bioactivity of insulin-likegrowth factor (IGF)-I. To test this hypothesis, we conducted a case-control study nested within a cohort of 14 275 women in New York. Methods: We used blood samples that had been obtained from these women from March 1985 through June 1991 and stored in a biorepository. C-peptide (a marker for insulin secretion), IGF-I, and IGF-binding proteins (IGFBPs)-1, -2, and -3 were assayed in the serum of 102 women who subsequently developed colorectal cancer and 200 matched control subjects. Logistic regression was used to relate cancer risk to these peptide levels, by adjustment for other risk factors. All statistical tests used are two-sided. Results: Colorectal cancer riskincreased with increasing levels of C-peptide (P-trend = .001), up to an odds ratio (OR) of 2.92 (95% confidence interval [CI] = 1.26-6.75) for the highest versus the lowest quintiles, after adjustment for smoking. For coloncancer alone (75 case subjects and 146 control subjects), ORs increased upto 3.96 (95% CI = 1.49-10.50; Pt-rend <.001) for the highest versus the lowest quintiles, A statistically significant decrease in colorectal cancer risk was observed for increasing levels of IGFBP-1 (P-trend = .02; OR in theupper quintile = 0.48 [95% CI = 0.23-1.00]), as well as for the highest quintile of IGFBP-2 levels (P-trend = .06; OR = 0.38 [95% CI = 0.15-0.94]). Colorectal cancer risk showed a modest but statistically nonsignificant positive association with levels of IGF-I and was statistically significantly increased for the highest quintile of IGFBP-3 (OR = 2.46 [95% CI = 1.09-5.57]). Conclusions: Chronically high levels of circulating insulin and IGFs associated with a Western lifestyle may increase colorectal cancer risk, possibly by decreasing IGFBP-1 and increasing the bioactivity of IGF-I.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 20:10:45