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Titolo:
Adsorptive stripping voltammetric determination of the antidepressant drugsulpiride
Autore:
Farghaly, OAE;
Indirizzi:
S Valley Univ, Fac Sci Qena, Dept Chem, Qena 83523, Egypt S Valley Univ Qena Egypt 83523 ac Sci Qena, Dept Chem, Qena 83523, Egypt
Titolo Testata:
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
fascicolo: 5, volume: 23, anno: 2000,
pagine: 783 - 791
SICI:
0731-7085(200010)23:5<783:ASVDOT>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIQUID-CHROMATOGRAPHY; BEHAVIOR;
Keywords:
cathodic stripping voltammetric determination of sulpiride; dogmatil fort tablets; urine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Farghaly, OAE S Valley Univ, Fac Sci Qena, Dept Chem, Qena 83523, Egypt S Valley Univ Qena Egypt 83523 ept Chem, Qena 83523, Egypt
Citazione:
O.A.E. Farghaly, "Adsorptive stripping voltammetric determination of the antidepressant drugsulpiride", J PHARM B, 23(5), 2000, pp. 783-791

Abstract

The electrochemical behaviour of the antidepressant drug sulpiride (SP) ata hanging mercury drop electrode (HMDE) is investigated. Linear sweep cathodic stripping voltammetry (LSCSV) was used to determine sulpiride in the presence of 0.01 M sodium acetate medium pH 10.5 and 25 +/- 1 degrees C. Different parameters such as, supporting electrolyte, pH, accumulation potential, scan rate, accumulation time and ionic strength, were tested to optimize the conditions for the determination of SP. The adsorbed form is reduced irreversibly. The linear concentration range is from 2x10(-9) to 5x10(-8) MSP. Experimentally, 2x10(-9) M (0.68 ppb) with accumulation time 60 s can be determined successfully. Furthermore, a theoretical detection limit of 2x 10(-10) M (0.068 ppb) Sp was calculated. The interferences of some metalions, ascorbic acid and some amino acids were studied. The method was applied to the analysis of tablets and spiked urine, with recoveries of 104 +/-3 and 101 +/- 3, and the relative standard deviation of 3.3 and 3.4%, respectively. (C) 2000 Elsevier Science B.V. All rights reserved.

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Documento generato il 03/04/20 alle ore 11:00:01