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Titolo:
Altered effects of an A(1) adenosine receptor agonist on the evoked responses of spinal dorsal horn neurones in a rat model of mononeuropathy
Autore:
Suzuki, R; Gale, A; Dickenson, AH;
Indirizzi:
Univ London Univ Coll, Dept Pharmacol, London WC1E 6BT, England Univ London Univ Coll London England WC1E 6BT , London WC1E 6BT, England
Titolo Testata:
JOURNAL OF PAIN
fascicolo: 2, volume: 1, anno: 2000,
pagine: 99 - 110
SICI:
1526-5900(200022)1:2<99:AEOAAA>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
R-PHENYLISOPROPYL-ADENOSINE; LONG-TERM POTENTIATION; NEUROPATHIC PAIN; INTRATHECAL ADENOSINE; PRESYNAPTIC INHIBITION; SUBSTANTIA-GELATINOSA; PERIPHERAL NEUROPATHY; SYNAPTIC TRANSMISSION; NOCICEPTIVE BEHAVIORS; GLUTAMATE RELEASE;
Keywords:
adenosine; CPA; nerve injury; antinociception; spinal cord;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Suzuki, R Univ London Univ Coll, Dept Pharmacol, Gower St, London WC1E 6BT, England Univ London Univ Coll Gower St London England WC1E 6BT England
Citazione:
R. Suzuki et al., "Altered effects of an A(1) adenosine receptor agonist on the evoked responses of spinal dorsal horn neurones in a rat model of mononeuropathy", J PAIN, 1(2), 2000, pp. 99-110

Abstract

There is clinical evidence that adenosine might be a useful treatment for neuropathic pain states, although little is known regarding its mechanisms. In this study, we use the selective (L5/L6) spinal nerve ligation model toinvestigate the effects of an adenosine A(1) receptor agonist, N-6-cyclopentyladenosine (CPA), on the evoked responses of dorsal horn neurones after nerve injury in vivo. Two weeks after surgery, the responses of dorsal hornneurones to controlled electrical and natural (mechanical and thermal) stimuli were recorded and the effects of intrathecal CPA were compared betweennerve-ligated and sham-operated rats. CPA produced significant inhibitionsof the C-fiber-evoked response, postdischarge, wind-up, mechanical, and thermal-evoked responses in both groups, but only minor inhibitions of the A beta-fiber response. Overall, the drug effects in spinal nerve-ligated ratswere greater than those of sham-operated rats. Spinal theophylline reversed these inhibitions. In contrast, CPA produced marked facilitations of the A delta-fiber-evoked neuronal responses in sham-operated animals, yet this effect was completely absent after nerve injury. These results suggest thatnerve injury induces plasticity in the spinal A(1) receptor system, which might form the basis for the therapeutic use of adenosine.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 15:37:19