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Titolo:
Functionally-defined compartments of the lordosis neural circuit in the ventromedial hypothalamus in female rats
Autore:
Daniels, D; Flanagan-Cato, LM;
Indirizzi:
Univ Penn, Dept Psychol, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 t Psychol, Philadelphia, PA 19104 USA Univ Penn, Inst Neurol Sci, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 eurol Sci, Philadelphia, PA 19104 USA
Titolo Testata:
JOURNAL OF NEUROBIOLOGY
fascicolo: 1, volume: 45, anno: 2000,
pagine: 1 - 13
SICI:
0022-3034(200010)45:1<1:FCOTLN>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
OXYTOCIN RECEPTOR-BINDING; CENTRAL-NERVOUS-SYSTEM; PARASYMPATHETIC PREGANGLIONIC NEURONS; MESSENGER-RNA EXPRESSION; PSEUDORABIES VIRUS; SEXUAL RECEPTIVITY; TRANSNEURONAL TRANSPORT; INTRACEREBRAL IMPLANTS; ESTRADIOL BENZOATE; AXONAL PROJECTIONS;
Keywords:
estrogen; lumbar epaxial muscles; oxytocin; pseudorabies virus; sexual behavior;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
78
Recensione:
Indirizzi per estratti:
Indirizzo: Daniels, D Univ Penn, Dept Psychol, 3815 Walnut St, Philadelphia, PA 19104USA Univ Penn 3815 Walnut St Philadelphia PA USA 19104 PA 19104 USA
Citazione:
D. Daniels e L.M. Flanagan-Cato, "Functionally-defined compartments of the lordosis neural circuit in the ventromedial hypothalamus in female rats", J NEUROBIOL, 45(1), 2000, pp. 1-13

Abstract

Sexual behavior in female rats, typified by the lordosis reflex, is dependent upon estrogen action in the ventromedial nucleus of the hypothalamus (VMH) and its surrounding neuropil, However, the synaptic organization of this brain region remains unclear. Pseudorabies virus (PRV) was used to transneuronally label the neural network that innervates the lumbar epaxial muscles that execute the lordosis response, PRV-labeled neurons were identified within and subjacent to the VMH four days after injection of PRV into the back muscles, The pattern of labeling was defined in relation to three landmarks: the VMH core, as defined by Crystal Violet staining; the shell, as defined by the oxytocin fiber tract; and the cluster of estrogen receptor-containing cell nuclei. The pattern of PRV labeling in the VMH displayed a striking rostral-caudal gradient. In general, many of the PRV-labeled neurons were found in the oxytocin fiber tract, with far fewer in the core of the VMH. Furthermore, PRV-labeled neurons were rarely found in the cluster of estrogen receptor-containing neurons, and less than 3% of the PRV-labeled neurons were double labeled for estrogen receptor. The results suggest that oxytocin may directly influence these lordosis-relevant VMH projection neurons, whereas estrogen may have transsynaptic effects. (C) 2000 John Wiley & Sons, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 02:29:35