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Titolo:
Myocardial perfusion scintigraphy as a screening method for significant coronary artery stenosis in cardiac transplant recipients
Autore:
Carlsen, J; Toft, JC; Mortensen, SA; Arendrup, H; Aldershvile, J; Hesse, B;
Indirizzi:
Univ Copenhagen Hosp, Rigshosp, Div Cardiol, Med Dept B 2141, DK-2100 Copenhagen, Denmark Univ Copenhagen Hosp Copenhagen Denmark DK-2100 2100 Copenhagen, Denmark Copenhagen Univ Hosp, Rigshosp, Ctr Imaging & Med Engn, Dept Clin Physiol & Nucl Med, Copenhagen, Denmark Copenhagen Univ Hosp Copenhagen Denmark & Nucl Med, Copenhagen, Denmark Copenhagen Univ Hosp, Rigshosp, Ctr Heart, Dept Cardiothorac Surg, Copenhagen, Denmark Copenhagen Univ Hosp Copenhagen Denmark horac Surg, Copenhagen, Denmark
Titolo Testata:
JOURNAL OF HEART AND LUNG TRANSPLANTATION
fascicolo: 9, volume: 19, anno: 2000,
pagine: 873 - 878
SICI:
1053-2498(200009)19:9<873:MPSAAS>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXERCISE THALLIUM SCINTIGRAPHY; HEART-TRANSPLANTATION; ALLOGRAFT VASCULOPATHY; DISEASE; TL-201; ATHEROSCLEROSIS; ANGIOPLASTY; EFFICACY; SPECT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Carlsen, J Univ Copenhagen Hosp, Rigshosp, Div Cardiol, Med Dept B 2141, Blegdamsvej,DK-2100 Copenhagen, Denmark Univ Copenhagen Hosp Blegdamsvej Copenhagen Denmark DK-2100 rk
Citazione:
J. Carlsen et al., "Myocardial perfusion scintigraphy as a screening method for significant coronary artery stenosis in cardiac transplant recipients", J HEART LUN, 19(9), 2000, pp. 873-878

Abstract

Background: Several studies have explored the feasibility of using myocardial perfusion imaging to detect allograft vasculopathy after heart transplantation. We undertook the present prospective consecutive study to comparatively evaluate the role of serial myocardial perfusion single-photon emission computed tomography (SPECT) scanning and coronary arteriography (CAG) indetecting coronary artery stenosis suitable for coronary angioplasty in heart transplant recipients. Methods: Within a 2-week interval during a follow-up period of 5.6 (95% confidence limits 2.1 to 12) years, 255 serial CAGs and myocardial perfusion scintigraphies were performed in 67 patients. Arteriography and scintigraphy were performed once yearly after heart transplantation. We retrospectively analyzed the data. Results: Myocardial scintigraphy showed pathologic reversible defects in 9out of 67 patients. Four of these patients had significant (>50% and also >70%) focal segmental stenosis in the middle and proximal parts of the coronary arteries (Type A lesions), 1 had diffuse and circumferential narrowingin the distal parts (Type B lesions), whereas CAG showed no lesions in theremaining 4 patients. The patients with significant Type A lesions were revascularized with percutaneous coronary angioplasty. Coronary arteriographyshowed that 1 patient had extensive Type A and Type B lesions, whereas myocardial perfusion scans detected no. The predictive value of a negative (normal) SPECT was 98% (95% confidence limits 94% to 100%) for the detection of lesions suited for revascularization. Conclusions: Annual myocardial SPECT seems well suited to screen for significant coronary artery stenosis. A SPECT study without reversible defects virtually excludes lesions, suitable for coronary artery revascularization.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 16:08:14