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Titolo:
Origin of neuronal nitric oxide synthase (NOS) - Immunoreactive fibers in guinea pig parasympathetic cardiac ganglia
Autore:
Calupca, MA; Vizzard, MA; Parsons, RL;
Indirizzi:
Univ Vermont, Coll Med, Dept Anat & Neurobiol, Burlington, VT 05405 USA Univ Vermont Burlington VT USA 05405 Neurobiol, Burlington, VT 05405 USA Univ Vermont, Coll Med, Dept Neurol, Burlington, VT 05405 USA Univ Vermont Burlington VT USA 05405 ept Neurol, Burlington, VT 05405 USA
Titolo Testata:
JOURNAL OF COMPARATIVE NEUROLOGY
fascicolo: 3, volume: 426, anno: 2000,
pagine: 493 - 504
SICI:
0021-9967(20001023)426:3<493:OONNOS>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
NADPH-DIAPHORASE; NEUROPEPTIDE-Y; SUBSTANCE-P; NERVE-FIBERS; HORSERADISH-PEROXIDASE; PREGANGLIONIC NEURONS; ANTEROGRADE TRANSPORT; INTRACARDIAC NEURONS; TYROSINE-HYDROXYLASE; INTRINSIC NEURONS;
Keywords:
NOS; vagal afferent fibers; nodose;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Parsons, RL Univ Vermont, Coll Med, Dept Anat & Neurobiol, Burlington, VT 05405 USA Univ Vermont Burlington VT USA 05405 Burlington, VT 05405 USA
Citazione:
M.A. Calupca et al., "Origin of neuronal nitric oxide synthase (NOS) - Immunoreactive fibers in guinea pig parasympathetic cardiac ganglia", J COMP NEUR, 426(3), 2000, pp. 493-504

Abstract

This study was conducted to determine the origin(s) of neuronal nitric oxide synthase-immunoreactive (NOS-IR) fibers within guinea pig atrial whole-mount preparations containing the cardiac ganglia. Intrinsic NOS-IR cardiac neurons exhibited choline acetyltransferase (ChAT) immunoreactivity, indicating that they were cholinergic as well as nitrergic. Comparison of controlversus 72-hour explant culture preparations indicated that most of the nitrergic fibers within cardiac ganglia were extrinsic. The extrinsic NOS-IR fibers were not IR for ChAT (marker of preganglionic parasympathetic neurons), tyrosine hydroxylase (marker of catecholaminergic sympathetic postganglionic axons), or calcitonin gene-related peptide (CGRP) (marker of afferent fibers). Separate NOS-IR and ChAT-IR neurons were present within medullary regions containing the cardiovascular regulatory nuclei (nucleus ambiguus and dorsal motor nucleus of the vagus), but no cells were found that exhibited both NOS immunoreactivity and ChAT immunoreactivity. The small size and location of the medullary NOS-IR neurons suggested they were probably interneurons. Only an occasional sympathetic postganglionic cell in the stellateganglion complex exhibited NOS immunoreactivity. NOS-IR cells were presentin dorsal root ganglia (thoracic 1-5), but these typically also exhibited CORP immunoreactivity. NOS-IR cells were also present in the nodose ganglia, but only some exhibited CORP immunoreactivity. We concluded that virtually all the extrinsic NOS-IR nerve fibers represented an afferent fiber inputthat was separate from the substance P (SP)/CGRP-containing population of sensory fibers. Furthermore, much of this NOS innervation is probably derived from the nodose ganglia. (C) 2000 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 12:11:35