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Titolo:
Xarvcf, Xenopus member of the p120 catenin subfamily associating with cadherin juxtamembrane region
Autore:
Paulson, AF; Mooney, E; Fang, X; Ji, H; McCrea, PD;
Indirizzi:
Univ Texas, MD Anderson Canc Ctr, Dept Biochem & Mol Biol 117, Program Genes & Dev, Houston, TX 77030 USA Univ Texas Houston TX USA 77030 rogram Genes & Dev, Houston, TX 77030 USA
Titolo Testata:
JOURNAL OF BIOLOGICAL CHEMISTRY
fascicolo: 39, volume: 275, anno: 2000,
pagine: 30124 - 30131
SICI:
0021-9258(20000929)275:39<30124:XXMOTP>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEMBRANE-PROXIMAL REGION; ARMADILLO FAMILY MEMBER; SEGMENT POLARITY GENE; TYROSINE PHOSPHORYLATION; CYTOPLASMIC DOMAIN; DESMOSOMAL PLAQUE; CELL-ADHESION; BETA-CATENIN; TRANSCRIPTION FACTOR; ENDOTHELIAL-CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
62
Recensione:
Indirizzi per estratti:
Indirizzo: McCrea, PD Univ Texas, MD Anderson Canc Ctr, Dept Biochem & Mol Biol 117, Program Genes & Dev, 1515 Holcombe Blvd, Houston, TX 77030 USA Univ Texas 1515 Holcombe Blvd Houston TX USA 77030 TX 77030 USA
Citazione:
A.F. Paulson et al., "Xarvcf, Xenopus member of the p120 catenin subfamily associating with cadherin juxtamembrane region", J BIOL CHEM, 275(39), 2000, pp. 30124-30131

Abstract

The catenin ARVCF is a member of the p120(ctn) subfamily of Armadillo proteins. A number of catenins directly bind cadherin cytoplasmic tails, contributing to the modulation of cell-cell adhesion and motility processes. Somecatenins, such as beta-catenin (and likely p120(ctn)), have additional roles within signaling pathways regulating gene transcription. We have isolated the Xenopus homolog of human ARVCF. Utilizing the cadherin membrane proximal region known to bind p120(ctn) and delta-catenin, coimmunoprecipitationexperiments demonstrate that Xarvcf, likewise, binds cadherin in this region and that corresponding point mutations within conserved residues abrogate the Xarvcf cadherin association. Western blot analysis of Xarvcf protein across a series of developmental stages reveals changes in protein mobility, likely due to changes in phosphorylation. Xarvcf is a maternally providedtranscript and expressed in the embryo throughout all stages of development. Interestingly, Xarvcf mRNA is differentially spliced to produce several isoforms, one of which is developmentally regulated. In common with the putative post-translational modifications of the Xarvcf protein, the presence of alternative splice isoforms suggests that Xarvcf possesses the capacity to effect developmental functions in a regulatable manner.

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Documento generato il 05/07/20 alle ore 11:48:41