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Titolo:
THE ROLE OF GLUCOSE-6-PHOSPHATE IN THE CONTROL OF GLYCOGEN-SYNTHASE
Autore:
VILLARPALASI C; GUINOVART JJ;
Indirizzi:
UNIV VIRGINIA,SCH MED,DEPT PHARMACOL CHARLOTTESVILLE VA 22908 UNIV BARCELONA,DEPT BIOQUIM & BIOL MOL E-08028 BARCELONA SPAIN
Titolo Testata:
The FASEB journal
fascicolo: 7, volume: 11, anno: 1997,
pagine: 544 - 558
SICI:
0892-6638(1997)11:7<544:TROGIT>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEPENDENT PROTEIN-KINASE; RABBIT SKELETAL-MUSCLE; BC3H-1 CELL-LINE; RAT HEPATOCYTES; CYCLIC-AMP; INSULIN RESISTANCE; SIGNALING PATHWAYS; DIABETIC RATS; GLUCOSE-6-PHOSPHATE PLAYS; PHOSPHATASE INHIBITOR-1;
Keywords:
GLUCOSE TRANSPORT; GLUCOSE PHOSPHORYLATION; INSULIN;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
121
Recensione:
Indirizzi per estratti:
Citazione:
C. Villarpalasi e J.J. Guinovart, "THE ROLE OF GLUCOSE-6-PHOSPHATE IN THE CONTROL OF GLYCOGEN-SYNTHASE", The FASEB journal, 11(7), 1997, pp. 544-558

Abstract

Elevated blood glucose concentrations result in increased intracellular levels of glucose 6-phosphate in liver, skeletal muscle, and adipose tissue. In liver, blood glucose concentrations are the main factor in control of the synthesis of glycogen; insulin has only a potentiating effect. In skeletal muscle and adipocytes, glucose alone has little effect on the activity of glycogen synthase, the limiting enzyme in glycogen synthesis. However, insulin released as a result of elevated blood glucose stimulates the translocation of specific glucose transporters to the cell membrane, increases the uptake of glucose, and causes the covalent, dephosphorylation-mediated activation of glycogen synthase. We present evidence that elevated intracellular contents of glucose 6-phosphate provoke the activation of glycogen synthase in liver, muscle, and adipose tissue. In addition, glucose 6-phosphate may inhibitthe phosphorylation of glycogen synthase by cyclic AMP-stimulated protein kinase. We show that the stimulated glucose uptake and phosphorylation appear to play a major role in the control by insulin of the enzymes involved in glycogen synthesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 19:16:08