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Titolo:
The efficacy of zotepine in treating acute negative symptoms of schizophrenia: The results of a meta-analysis
Autore:
Wighton, A; Tweed, JA; Butler, A; Welch, CP; Reynolds, C; Bratty, JR;
Indirizzi:
Knoll Pharmaceut, Nottingham NG1 7AR, England Knoll Pharmaceut Nottingham England NG1 7AR Nottingham NG1 7AR, England
Titolo Testata:
INTERNATIONAL JOURNAL OF PSYCHIATRY IN CLINICAL PRACTICE
fascicolo: 3, volume: 4, anno: 2000,
pagine: 209 - 214
SICI:
1365-1501(200009)4:3<209:TEOZIT>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOUBLE-BLIND TRIAL; RITANSERIN; HALOPERIDOL; RISPERIDONE; ANTAGONIST; METAANALYSIS; DISORDERS; PLACEBO; DRUGS;
Keywords:
zotepine; schizophrenia; negative symptoms; SANS; meta-analysis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Wighton, A Knoll Pharmaceut, St Nicholos Court,25-27 Castle Gate, Nottingham NG1 7AR,England Knoll Pharmaceut St Nicholos Court,25-27 Castle Gate Nottingham England NG1 7AR
Citazione:
A. Wighton et al., "The efficacy of zotepine in treating acute negative symptoms of schizophrenia: The results of a meta-analysis", INT J PSYC, 4(3), 2000, pp. 209-214

Abstract

INTRODUCTION: Zotepine is a unique antipsychotic drug, having effects which are both antiserotonergic and antidopaminergic that may make it mol-e effective in the treatment of negative symptoms of schizophrenia than more conventional agents. METHOD: A meta-analysis was performed on the effect of zotepine on the negative symptoms in seven double-blind studies, as measured by the SANS scale. RESULTS: Of the trials selected for this meta-analysis, one skewed significant improvement in acute negative symptoms in favour of zotepine. Negativesymptoms measured in the other trials showed trends in favour of zotepine,except for one study where the trend was in favour of perazine. The meta-analysis showed zotepine to he significantly better then either placebo or conventional antipsychotic comparators using the standardized treatment difference methodology, and it confirmed the results from a previous study using patients with predominantly negative symptoms. CONCLUSION: Zotepine may have a place in the treatment of this group of patients where conventional antiypsychotic drugs have had little effect.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 10:39:00