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Titolo:
Ovarian steroid and cytokine modulation of human endometrial angiogenesis
Autore:
Lebovic, DI; Shifren, JL; Ryan, IP; Mueller, MD; Korn, AP; Darney, PD; Taylor, RN;
Indirizzi:
Univ Calif San Francisco, Dept Obstet Gynecol & Reprod Sci, Reprod Endocrinol Ctr, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Univ Calif San Francisco, San Francisco Gen Hosp, Ctr Reprod Sci, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Univ Calif San Francisco, Ctr Family Planning Res, San Francisco, CA 94143USA Univ Calif San Francisco San Francisco CA USA 94143 rancisco, CA 94143USA
Titolo Testata:
HUMAN REPRODUCTION
, volume: 15, anno: 2000, supplemento:, 3
pagine: 67 - 77
SICI:
0268-1161(200008)15:<67:OSACMO>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIAL GROWTH-FACTOR; NORMAL MENSTRUAL-CYCLE; ESTROGEN-RESPONSIVE ELEMENT; MESSENGER-RIBONUCLEIC-ACID; NECROSIS-FACTOR-ALPHA; STROMAL CELLS; FACTOR VEGF; MEDROXYPROGESTERONE ACETATE; PROGESTERONE RECEPTORS; BLEEDING PATTERNS;
Keywords:
bleeding; Norplant; progestins; uterus; VEGF;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
76
Recensione:
Indirizzi per estratti:
Indirizzo: Taylor, RN Univ Calif San Francisco, Dept Obstet Gynecol & Reprod Sci, Reprod Endocrinol Ctr, San Francisco HSE 1689,Box 0556, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco HSE 1689,Box 0556 San Francisco CA USA 94143
Citazione:
D.I. Lebovic et al., "Ovarian steroid and cytokine modulation of human endometrial angiogenesis", HUM REPR, 15, 2000, pp. 67-77

Abstract

A key mechanism underlying the cyclical growth of the endometrium is its ability to regenerate a vascular capillary network. In normal cycling human endometrium, angiogenesis is influenced by both endocrine and paracrine factors. Hormonal manipulation of the endometrium, such as that occurring during the use of steroidal contraception, appears to result in capillary proliferation and fragility. As a consequence of these vascular changes, contraceptive users may be predisposed to unpredictable uterine bleeding, which isresponsible for the high frequency of contraceptive discontinuation. In this paper we address mechanisms responsible for vascular endothelial cell proliferation in normal and contraceptive steroid-exposed endometria, We propose that regulation of endometrial angiogenesis is mediated indirectly, viasteroid and cytokine actions on vascular endothelial growth factor (VEGF),and we present data indicating that VEGF expression in normal endometrial stromal cells is increased by oestrogens and progestins, Three proinflammatory cytokines with angiogenic effects in other systems (i.e. interleukin-1 beta, tumour necrosis factor-alpha and interferon-gamma) do not appear to up-regulate VEGF expression in normal endometrial stromal cells. Well-characterized in-vitro models in conjunction with immunohistochemistry provide useful experimental systems to study endometrial neovascularization under physiological conditions and in those potentially perturbed via the use of contraceptive steroids.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 13:43:28