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Titolo:
Intraoperative radiotherapy and bypass surgery for unresectable pancreaticcancer
Autore:
Ishikawa, H; Suzuki, Y; Nakayama, Y; Nakamoto, S; Kusaba, T; Kakinuma, S; Sakata, Y; Mitsuhashi, N; Niibe, H;
Indirizzi:
Gunma Univ, Sch Med, Dept Radiol & Radiat Oncol, Maebashi, Gumma 3718511, Japan Gunma Univ Maebashi Gumma Japan 3718511 l, Maebashi, Gumma 3718511, Japan Natl Takasaki Hosp, Dept Radiol, Takasaki, Gumma, Japan Natl Takasaki Hosp Takasaki Gumma Japan t Radiol, Takasaki, Gumma, Japan Natl Takasaki Hosp, Dept Surg, Takasaki, Gumma, Japan Natl Takasaki Hosp Takasaki Gumma Japan ept Surg, Takasaki, Gumma, Japan
Titolo Testata:
HEPATO-GASTROENTEROLOGY
fascicolo: 34, volume: 47, anno: 2000,
pagine: 1151 - 1155
SICI:
0172-6390(200007/08)47:34<1151:IRABSF>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
RADIATION-THERAPY; EXTERNAL-BEAM; HYPERTHERMIA; IRRADIATION; CARCINOMA; ADENOCARCINOMA; COMBINATION; EXPERIENCE;
Keywords:
unresectable pancreatic cancer; intraoperative radiotherapy; external beam radiotherapy; bypass surgery;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Ishikawa, H Gunma Univ, Sch Med, Dept Radiol & Radiat Oncol, 3-39-22 ShowaMachi, Maebashi, Gumma 3718511, Japan Gunma Univ 3-39-22 Showa Machi Maebashi Gumma Japan 3718511 an
Citazione:
H. Ishikawa et al., "Intraoperative radiotherapy and bypass surgery for unresectable pancreaticcancer", HEP-GASTRO, 47(34), 2000, pp. 1151-1155

Abstract

Background/Aims: Conflicting results have been reported concerning the usefulness of radiotherapy for unresectable pancreatic cancer. We evaluated the clinical efficacy of intraoperative radiotherapy and/or external beam radiotherapy in combination with bypass surgery. Methodology: Twenty-six patients with unresectable pancreatic cancer (16 in Stage II-III and 10 in Stage IV) were treated with intraoperative radiotherapy plus external beam radiotherapy (16 patients) or intraoperative radiotherapy alone (10 patients). The dose of intraoperative radiotherapy was either 25 or 30Gy and the external beam radiotherapy dose was 31-60Gy. The feasibility and clinical outcome were analyzed. Results: The median survival time for Stage II-III and Stage IV were 11.5 and 6.5 months, respectively. The difference between Stage II-III and StageIV in survival. patterns was statistically significant (P<0.05). For StageII-III patients, the survival curves between the groups of intraoperative radiotherapy plus external beam radiotherapy and intraoperative radiotherapy alone were not significantly different, and only performance status was asignificant factor in the prognosis (P<0.05). Gastrointestinal bleeding was noted in 8%, but did not occur in the patients treated with an external beam radiotherapy dose less than 50Gy. Palliative radiation was successfullyperformed to relieve pain, jaundice and appetite-loss and to shorten the hospital stay. Conclusions: The combination therapy with intraoperative radiotherapy and bypass surgery is considered to be tolerable and effective for unresectablepancreatic cancer, and also may improve the quality of life of the patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 08:34:27