Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
SERUM CONCENTRATIONS OF FREE UBIQUITIN AND MULTIUBIQUITIN CHAINS
Autore:
TAKADA K; NASU H; HIBI N; TSUKADA Y; SHIBASAKI T; FUJISE K; FUJIMURO M; SAWADA H; YOKOSAWA H; OHKAWA K;
Indirizzi:
JIKEI UNIV,SCH MED,DEPT BIOCHEM 1,MINATO KU TOKYO 105 JAPAN JIKEI UNIV,SCH MED,DEPT INTERNAL MED 2,MINATO KU TOKYO 105 JAPAN JIKEI UNIV,SCH MED,DEPT INTERNAL MED,KASHIWA HOSP,MINATO KU TOKYO 105JAPAN SRL INC,DEPT RES LAB HACHIOJI TOKYO 192 JAPAN HOKKAIDO UNIV,FAC PHARMACEUT SCI,DEPT BIOCHEM SAPPORO HOKKAIDO 060 JAPAN
Titolo Testata:
Clinical chemistry
fascicolo: 7, volume: 43, anno: 1997,
pagine: 1188 - 1195
SICI:
0009-9147(1997)43:7<1188:SCOFUA>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBROSPINAL-FLUID; PROTEIN-DEGRADATION; ALZHEIMERS-DISEASE; REVISED CRITERIA; HEAT-SHOCK; PATHWAY; INVOLVEMENT; INCREASE; IMMUNOREACTIVITY; QUANTIFICATION;
Keywords:
RADIOIMMUNOASSAY; ENZYME-LINKED IMMUNOSORBENT ASSAY; HEMOLYSIS; HEMODIALYSIS; RHEUMATOID ARTHRITIS; ACUTE VIRAL HEPATITIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
K. Takada et al., "SERUM CONCENTRATIONS OF FREE UBIQUITIN AND MULTIUBIQUITIN CHAINS", Clinical chemistry, 43(7), 1997, pp. 1188-1195

Abstract

Ubiquitin, which can conjugate with cellular proteins, is classified into two forms: free ubiquitin and multiubiquitin chains. The latter is active as a signal for degradation of the targeted proteins. We found both forms in human serum and, using two immunoassays, quantitated them in sera from healthy subjects and patients with some diseases. Because of putative leakage of erythrocyte ubiquitin, hemolytic serum andserum obtained after long incubation (> 1-2 h) of blood at room temperature were excluded. Serum concentrations of multiubiquitin chains and free ubiquitin were substantially higher in rheumatoid arthritis andhemodialysis patients, respectively, than healthy subjects. Additionally, in acute viral hepatitis, serum multiubiquitin chain concentrations were increased in the acute phase, decreased in the recovery phase,and correlated with alanine and aspartate aminotransferase activities(r = 0.676 and 0.610, P < 0.0001 and < 0.001, respectively). Therefore, serum ubiquitin may have prognostic value.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 08:31:35