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Titolo:
Effect of acute atenolol on short-term blood pressure variability and baroreflex sensitivity in rats
Autore:
Neto, EPD; Frutoso, J; Somody, L; Gharib, C; Fortrat, JO;
Indirizzi:
Fac Med Lyon Grange Blanche, EA GIP Exercice 645, Environm Physiol Lab, F-69373 Lyon 08, France Fac Med Lyon Grange Blanche Lyon France 08 Lab, F-69373 Lyon 08, France Hop Cardiovasc & Pneumol Louis Pradel, F-69394 Lyon, France Hop Cardiovasc& Pneumol Louis Pradel Lyon France F-69394 4 Lyon, France
Titolo Testata:
FUNDAMENTAL & CLINICAL PHARMACOLOGY
fascicolo: 4, volume: 14, anno: 2000,
pagine: 341 - 349
SICI:
0767-3981(200007/08)14:4<341:EOAAOS>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEART-RATE-VARIABILITY; SPECTRAL-ANALYSIS; CARDIOVASCULAR VARIABILITY; AUTONOMIC REGULATION; SINUS ARRHYTHMIA; ANESTHETIZED CAT; NERVOUS-SYSTEM; HYPERTENSION; BLOCKADE; BLOCKERS;
Keywords:
antihypertensive agents; autonomic nervous system; baroreflex sensitivity; spectral analysis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Neto, EPD Fac Med Lyon Grange Blanche, EA GIP Exercice 645, Environm Physiol Lab, 8 Ave Rockefeller, F-69373 Lyon 08, France Fac Med Lyon Grange Blanche 8 Ave Rockefeller Lyon France 08 ce
Citazione:
E.P.D. Neto et al., "Effect of acute atenolol on short-term blood pressure variability and baroreflex sensitivity in rats", FUN CL PHAR, 14(4), 2000, pp. 341-349

Abstract

Beta-blocker therapy for hypertension or coronary artery disease is common, but there are a lot of controversies about its effects on short-term blood pressure variability and arterial baroreceptor reflexes. The aim of this study was to evaluate the effects of acute atenolol on baroreflex sensitivity (BRS) and on the spontaneous variability of systolic blood pressure (SBP) and RR intervals in conscious rats. Ten Wistar rats equipped with telemetry system were evaluated: 1) under control conditions; 2) after injection of saline; and 3) during beta(1)-adrenergic blockade by atenolol. Fast Fourier transform analysis was applied to RR intervals and SEP. Atenolol increased RR intervals significantly by 14% and the variation coefficient of the RR intervals by 31%. SEP was reduced significantly by 9%. In frequency domain, beta(1)-blockade in RR intervals increased very low frequency by 33%, and the total power by 22% and decreased low frequency by 25%. The ratio of low to high frequency power decreased by 60%. Frequency domain variables in SEP were not significantly changed after beta(1)-adrenergic receptor blockade. BRS (gain alpha) was not significantly altered by beta-blockers. Acute atenolol decreased SEP and increased RR intervals with no change in BRS, indicating 'resetting' of baroreflex function. (C) 2000 Editions scientifiques el medicales Elsevier SAS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 10:24:21