Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
IMMUNOLOGICAL AND VIROLOGICAL EVALUATION AFTER INFLUENZA VACCINATION OF HIV-1-INFECTED PATIENTS
Autore:
FOWKE KR; DAMICO R; CHERNOFF DN; POTTAGE JC; BENSON CA; SHA BE; KESSLER HA; LANDAY AL; SHEARER GM;
Indirizzi:
NCI,EXPT IMMUNOL BRANCH,NATL INST HLTH,4B17 BLDG 10,9000 ROCKVILLE PIKE BETHESDA MD 20892 NCI,EXPT IMMUNOL BRANCH,NATL INST HLTH BETHESDA MD 20892 RUSH MED COLL,DEPT IMMUNOL MICROBIOL CHICAGO IL 60612 RUSH MED COLL,DEPT MED CHICAGO IL 60612 CHIRON CORP EMERYVILLE CA 94608
Titolo Testata:
AIDS
fascicolo: 8, volume: 11, anno: 1997,
pagine: 1013 - 1021
SICI:
0269-9370(1997)11:8<1013:IAVEAI>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; HIV-SEROPOSITIVE INDIVIDUALS; PROGRAMMED CELL-DEATH; IMMUNE-RESPONSES; LYMPHOCYTES; ACTIVATION; APOPTOSIS; REPLICATION; INFECTION; INTERLEUKIN-2;
Keywords:
HIV; APOPTOSIS; INFLUENZA; IMMUNIZATION; VIRAL LOAD; T-CELL RESPONSE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
K.R. Fowke et al., "IMMUNOLOGICAL AND VIROLOGICAL EVALUATION AFTER INFLUENZA VACCINATION OF HIV-1-INFECTED PATIENTS", AIDS, 11(8), 1997, pp. 1013-1021

Abstract

Objective: The present study was designed to determine the effect of immune activation, achieved by influenza vaccination, on plasma HIV RNA levels and immunological parameters including CD4 cell levels, antigen-stimulated T-cell function and apoptotic death of peripheral blood mononuclear cells. Design and methods: Thirty-four HIV-infected individuals and nine uninfected controls were immunized with influenza vaccine and blood was collected at weeks 0, 2, 4 and 16. Plasma was isolated and used for HIV RNA and influenza-specific antibody quantifications. CD4 cell counts, activation and maturation markers of T-lymphocyte subsets were determined by flow cytometry. In vitro T-helper responses,spontaneous- and activation-induced cell death assays were also performed. Results: Influenza-specific humoral and cellular immune responses correlated with CD4 count. Only in patients with CD4 counts > 300 x 10(6)/l there was a modest increase in T-cell responses to influenza virus, which was less than control subjects, observed after vaccination. Immunization had no significant effect on CD4 counts or plasma virallevels in the HIV-positive patients. Baseline apoptosis inversely correlated with CD4 counts and directly correlated with viral load. Activation-induced apoptosis did not change appreciably after vaccination and spontaneous apoptosis increased only in the < 300 CD4 group. Conclusion: These results indicate that immune stimulation resulting from influenza vaccination did not significantly change the levels of plasma virus, CD4 cell counts, or activation-induced apoptosis in HIV-infected individuals, although an increase in the T-cell response to influenza and spontaneous apoptosis was observed in the > 300 and < 300 CD4 groups, respectively.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 12:35:55