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Titolo:
Steady state concentrations of clomipramine and its major metabolite desmethylclomipramine in rat brain and serum after oral administration of clomipramine
Autore:
Weigmann, H; Hartter, S; Bagli, M; Hiemke, C;
Indirizzi:
Univ Mainz, Dept Psychiat, D-55131 Mainz, Germany Univ Mainz Mainz Germany D-55131 , Dept Psychiat, D-55131 Mainz, Germany Univ Bonn, Dept Psychiat, D-5300 Bonn, Germany Univ Bonn Bonn Germany D-5300 Bonn, Dept Psychiat, D-5300 Bonn, Germany
Titolo Testata:
EUROPEAN NEUROPSYCHOPHARMACOLOGY
fascicolo: 5, volume: 10, anno: 2000,
pagine: 401 - 405
SICI:
0924-977X(200009)10:5<401:SSCOCA>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
CLINICAL PHARMACOKINETICS; PSYCHIATRIC-DISORDERS; BLOOD; CHLORIMIPRAMINE; PLASMA; TISSUE; DESMETHYLDIAZEPAM; PERSISTENCE; FLUVOXAMINE; FLUOXETINE;
Keywords:
clomipramine; desmethylclomipramine; steady state; serum concentration; brain concentration;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Hiemke, C Univ Mainz, Dept Psychiat, Untere Zahlbacher Str 8, D-55131 Mainz, Germany Univ Mainz Untere Zahlbacher Str 8 Mainz Germany D-55131 ermany
Citazione:
H. Weigmann et al., "Steady state concentrations of clomipramine and its major metabolite desmethylclomipramine in rat brain and serum after oral administration of clomipramine", EUR NEUROPS, 10(5), 2000, pp. 401-405

Abstract

Twenty male Sprague-Dawley rats received five oral doses of clomipramine 20 mg/kg at 4-h intervals. The animals were decapitated 1, 2, 3, 5 and 12 h after the last dose for determination of clomipramine and desmethylclomipramine in serum and frontal cerebral cortex. Time dependent concentrations ofclomipramine and desmethylclomipramine paralleled in serum and brain. Half-lives were similar in serum and brain with 7.8 versus 6.2 h and 5.5 versus5.0 h for clomipramine and desmethylclomipramine, respectively. Absolute concentrations, however, were markedly higher in brain than in serum - 12.5 fold for clomipramine and 7.4 fold for desmethyl clomipramine. The data indicate that serum and brain concentrations of clomipramine and its demethylated metabolite are rapidly exchanged between blood and brain. Assuming thatblood and brain kinetics in man and rat are comparable, it is concluded that monitoring blood concentrations of clomipramine and desmethylclomipramine is a useful way to evaluate brain concentrations. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 00:52:28