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Titolo:
Changes of cerebrospinal fluid monoamine metabolites during long-term antidepressant treatment
Autore:
Backman, J; Alling, C; Alsen, M; Regnell, G; Traskman-Bendz, L;
Indirizzi:
Univ Lund, Dept Clin Neurosci, Div Psychiat, Lund, Sweden Univ Lund LundSweden d, Dept Clin Neurosci, Div Psychiat, Lund, Sweden Univ Lund, Dept Lab Med, Div Med Neurochem, Lund, Sweden Univ Lund Lund Sweden nd, Dept Lab Med, Div Med Neurochem, Lund, Sweden
Titolo Testata:
EUROPEAN NEUROPSYCHOPHARMACOLOGY
fascicolo: 5, volume: 10, anno: 2000,
pagine: 341 - 349
SICI:
0924-977X(200009)10:5<341:COCFMM>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEROTONIN UPTAKE; DEPRESSION; PLASMA; IMIPRAMINE; FLUOXETINE; BRAIN; NOREPINEPHRINE; NORTRIPTYLINE; DESIPRAMINE; ZIMELIDINE;
Keywords:
antidepressants; cerebrospinal fluid; 5-HIAA; MHPG;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Traskman-Bendz, L Univ Lund Hosp, Ctr Psychiat, Dept Affect Disorders & Suicide Prevent, S-22185 Lund, Sweden Univ Lund Hosp Lund Sweden S-22185 -22185 Lund, Sweden
Citazione:
J. Backman et al., "Changes of cerebrospinal fluid monoamine metabolites during long-term antidepressant treatment", EUR NEUROPS, 10(5), 2000, pp. 341-349

Abstract

This study describes the changes in cerebrospinal fluid (CSF) monoamine metabolites during antidepressant treatment for more than 6 months. Eight patients, who received antidepressant treatment after attempted suicide and then underwent lumbar punctures every 3 or 4 months, were included. Plasma drug concentrations and the clinical outcome were also measured. Consistent with previous reports about antidepressant treatment for between 3 and 6 weeks, both 3-methoxy-4-hydroxyphenylethyleneglycol (MHPG) and 5-hydroxyindoleacetic acid (5-HIAA) were significantly decreased after treatment for a mean of 15 weeks compared to pretreatment. However, after continued treatment for a mean of 30 weeks the MHPG concentration remained significantly lower than at pretreatment while 5-HIAA had returned to the pretreatment level. The clinical outcome was significantly correlated to the pretreatment 5-HIAA/MHPG ratio. These results suggest that the frequently reported reduction in CSF 5-HIAA after antidepressant treatment does not remain during long-term treatment. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 16:29:30