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Titolo:
Effects of conantokins on L-3,4-dihydroxyphenylalanine-induced behavior and immediate early gene expression
Autore:
Adams, AC; Layer, RT; McCabe, RT; Keefe, KA;
Indirizzi:
Univ Utah, Dept Pharmacol & Toxicol, Salt Lake City, UT 84112 USA Univ Utah Salt Lake City UT USA 84112 xicol, Salt Lake City, UT 84112 USA
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 3, volume: 404, anno: 2000,
pagine: 303 - 313
SICI:
0014-2999(20000922)404:3<303:EOCOLB>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
D-ASPARTATE RECEPTOR; NMDA RECEPTOR; PARKINSONS-DISEASE; ANTIPARKINSONIAN ACTIONS; MESSENGER-RNA; L-DOPA; C-FOS; SQUIRREL-MONKEY; BASAL GANGLIA; ANTAGONISTS;
Keywords:
c-fos; zif268; 6-hydroxydopamine; N-methyl-D-aspartate (NMDA); L-3,4-dihydroxyphenylalanine (L-DOPA); striatum;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Keefe, KA Univ Utah, Dept Pharmacol & Toxicol, 30 S 2000 East,Room 201, Salt Lake City, UT 84112 USA Univ Utah 30 S 2000 East,Room 201 Salt Lake CityUT USA 84112 SA
Citazione:
A.C. Adams et al., "Effects of conantokins on L-3,4-dihydroxyphenylalanine-induced behavior and immediate early gene expression", EUR J PHARM, 404(3), 2000, pp. 303-313

Abstract

Conantokins, peptides from Conus snails, are N-methyl-D-aspartate (NMDA) receptor antagonists. NMDA receptor antagonists potentiate L-3,4-dihydroxyphenylalanine (L-DOPA)-induced rotation in 6-hydroxydopamine-treated rodents,an index of anti-parkinsonian potential. This study examined the effects of conantokin-G, conantokin-T(G), CGS 19755, and ifenprodil on L-DOPA-induced contralateral rotation and immediate early gene (IEG) expression in 6-hydroxydopamine-treated rats. Rats received unilateral infusions of 6-hydroxydopamine into the medial forebrain bundle. Three weeks later, rats were treated with an NMDA receptor antagonist, followed by an injection of L-DOPA. Contralateral rotations were recorded for 2 h. In addition, the expression of zif268 and c-fos were examined. Conantokin-G, conantokin-T(G), and CGS 19755 potentiated L-DOPA-induced rotation. Conantokin-G and ifenprodil had noeffect on L-DOPA-induced IEG expression, whereas conantokin-T(G) and CGS 19755 attenuated expression. These data suggest that conantokins may be useful in treating Parkinson's disease. Furthermore, different NMDA receptor antagonists have distinct effects on striatal gene expression. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 11:46:14