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Titolo:
PHARMACOLOGICAL CHARACTERIZATION OF THE VANILLOID RECEPTOR IN THE RATDORSAL SPINAL-CORD
Autore:
WARDLE KA; RANSON J; SANGER GJ;
Indirizzi:
SMITHKLINE BEECHAM PHARMACEUT,NEUROSCI RES,NEW FRONTIERS SCI PK HARLOW CM19 5AD ESSEX ENGLAND
Titolo Testata:
British Journal of Pharmacology
fascicolo: 5, volume: 121, anno: 1997,
pagine: 1012 - 1016
SICI:
0007-1188(1997)121:5<1012:PCOTVR>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
H-3 RESINIFERATOXIN BINDING; GENE-RELATED PEPTIDE; CAPSAICIN RECEPTOR; URINARY-BLADDER; SENSORY NEURONS; CAPSAZEPINE; CONOTOXIN; RESPONSES; RELEASE;
Keywords:
CAPSAICIN; VANILLOID; SPINAL CORD; OLVANIL; RESINIFERATOXIN (RTX); CAPSAZEPINE; RUTHENIUM RED;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
K.A. Wardle et al., "PHARMACOLOGICAL CHARACTERIZATION OF THE VANILLOID RECEPTOR IN THE RATDORSAL SPINAL-CORD", British Journal of Pharmacology, 121(5), 1997, pp. 1012-1016

Abstract

1 In the present study a novel 96-well plate assay system was used tocharacterize pharmacologically the vanilloid receptor in the dorsal spinal cord of the rat. When activated, this receptor stimulates release of calcitonin gene-related peptide (CGRP) from the central terminalsof the afferent nerves. 2 Capsaicin, resiniferatoxin (RTX) and olvanil each evoked a concentration-dependent increase in CGRP release with pEC(50) values of 6.55+/-0.07, 7.90+/-0.24 and 6.19+/-0.15 respectively. RTX and olvanil were partial agonists with respect to capsaicin. All concentration-effect curves were bell-shaped. 3 The vanilloid receptor antagonist, capsazepine (10 mu M) had no effect on basal peptide release but inhibited the CGRP release evoked by all 3 agonists to a similar extent. These results suggest that the antagonistic effects of capsazepine were agonist-independent. 4 The capsaicin-sensitive cation channel blocker, ruthenium red (10 mu M) had no effect on basal CGRP release, but antagonized the peptide release evoked by capsaicin, olvanil and RTX. 5 The pharmacology of the vanilloid receptor in the rat dorsal spinal cord is not identical to that previously found in other systems. The reason for these differences is unclear, but the possibilityof multiple classes of receptor cannot at this stage be ruled out.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 12:07:18