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Titolo:
Urinary soluble IL-6 receptor levels after cardiopulmonary bypass
Autore:
Sutherland, AG; Deehan, DJ;
Indirizzi:
Univ Aberdeen, Sch Med, Dept Orthopaed, Aberdeen AB25 2ZD, Scotland Univ Aberdeen Aberdeen Scotland AB25 2ZD ed, Aberdeen AB25 2ZD, Scotland Freeman Hosp, Dept Orthopaed, Newcastle Upon Tyne, Tyne & Wear, England Freeman Hosp Newcastle Upon Tyne Tyne & Wear England yne & Wear, England
Titolo Testata:
CYTOKINE
fascicolo: 9, volume: 12, anno: 2000,
pagine: 1441 - 1443
SICI:
1043-4666(200009)12:9<1441:USIRLA>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTERLEUKIN-6 RECEPTOR;
Keywords:
cardiopulmonary bypass; ECC; IL-6; soluble IL-6 receptor; surgical stress;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
13
Recensione:
Indirizzi per estratti:
Indirizzo: Sutherland, AG Univ Aberdeen, Sch Med, Dept Orthopaed, Polwarth Bldg, Aberdeen AB25 2ZD, Scotland Univ Aberdeen Polwarth Bldg Aberdeen Scotland AB252ZD and
Citazione:
A.G. Sutherland e D.J. Deehan, "Urinary soluble IL-6 receptor levels after cardiopulmonary bypass", CYTOKINE, 12(9), 2000, pp. 1441-1443

Abstract

To investigate the possible role of soluble interleukin 6 receptor (sIL-6r) in the inflammatory response to cardiopulmonary bypass (CPB) with extracorporeal circulation (ECC), we examined the levels of sIL-6r in the urine of50 patients undergoing coronary artery bypass surgery. The presence of sIL-6r in urine was confirmed in these patients, with levels rising from 6 pg/ml preoperatively to 19.5 pg/ml at 6 h and 41 pg/ml at 24 h after the startof cardiopulmonary bypass. Cardiopulmonary bypass leads to a rise in sIL-6r in urine that has not returned to normal after 24 h, suggesting a role for sIL-6r acid IL-6 in the inflammatory response to such surgery. Determination of cytokine receptor presence in urine offers a non-invasive approach to the monitoring of the immune and inflammatory response to the stress of surgical and traumatic injury. (C) 2000 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 00:46:52