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Titolo:
A noradrenergic and serotonergic hypothesis of the linkage between epilepsy and affective disorders
Autore:
Jobe, PC; Dailey, JW; Wernicke, JF;
Indirizzi:
Univ Illinois, Coll Med, Dept Biomed & Therapeut Sci, Peoria, IL 61656 USAUniv Illinois Peoria IL USA 61656 d & Therapeut Sci, Peoria, IL 61656 USA Ellyn Inc, Houston, TX USA Ellyn Inc Houston TX USAEllyn Inc, Houston, TX USA
Titolo Testata:
CRITICAL REVIEWS IN NEUROBIOLOGY
fascicolo: 4, volume: 13, anno: 1999,
pagine: 317 - 356
SICI:
0892-0915(1999)13:4<317:ANASHO>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; DEPRESSED SUICIDE VICTIMS; GAMMA-AMINOBUTYRIC-ACID; FREELY MOVING RATS; METHYL-D-ASPARTATE; GENERALIZED ABSENCE SEIZURES; SEASONAL AFFECTIVE-DISORDER; IMIPRAMINE BINDING-SITES; GROWTH-HORMONE RESPONSE; FLUID MONOAMINE METABOLITES;
Keywords:
epilepsy; affective disorder; seizure; convulsion; noradrenergic; serotonergic; GABAergic; glutamatergic; antiepileptic drugs; antidepressant drugs; vagal nerve stimulation; excitatory amino acids; NMDA receptor antagonists; genetically epilepsy-prone rats (GEPRs); learned helplessness; predisposition; genetics; environment;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
508
Recensione:
Indirizzi per estratti:
Indirizzo: Jobe, PC Univ Illinois, Coll Med, Dept Biomed & Therapeut Sci, Peoria, IL 61656 USA Univ Illinois Peoria IL USA 61656 peut Sci, Peoria, IL 61656 USA
Citazione:
P.C. Jobe et al., "A noradrenergic and serotonergic hypothesis of the linkage between epilepsy and affective disorders", CR R NEUR, 13(4), 1999, pp. 317-356

Abstract

Noradrenergic and/or serotonergic deficits, as well as other abnormalities, may contribute to predisposition to some epilepsies and depressions. Evidence for this hypothesis stems from several sources. Epidemiological investigations are intriguing but incomplete. Pharmacological studies show that noradrenergic and/or serotonergic transmission are both anticonvulsant and antidepressant. Therapeutically pertinent investigations show that antidepressant drugs have anticonvulsant properties, whereas antiepileptic drugs areeffective in the management of affective disorders. Additional investigations demonstrate that seizures, whether spontaneously occurring or therapeutically induced, protect against depression. Through studies of innate pathophysiology, noradrenergic and serotonergic deficits have been identified inindividuals with depression and in animal models of epilepsy, as well as in some humans with epilepsy. Vagal nerve stimulation, a treatment already known to be effective in the epilepsies, is presently under investigation for effectiveness in affective disorder. New evidence suggests that vagal nerve stimulation exerts at least some of its therapeutic effects through its capacity to increase noradrenergic and serotonergic transmission. Finally, emerging evidence supports the concept that some genetic mammalian models of the human epilepsies exhibit analogous manifestations of depression.

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Documento generato il 18/01/20 alle ore 08:02:48