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Titolo:
Activation of myocardial angiogenesis and upregulation of fibroblast growth factor-2 in transmyocardial-revascularization-treated mice
Autore:
Chiotti, K; Choo, SJ; Martin, SL; Reichert, C; Grass, TM; Duran, CMG; Coffin, JD;
Indirizzi:
Univ Montana, Dept Pharmaceut Sci, Missoula, MT 59812 USA Univ Montana Missoula MT USA 59812 Pharmaceut Sci, Missoula, MT 59812 USA McLaughlin Res Inst, Great Falls, MT USA McLaughlin Res Inst Great Falls MT USA lin Res Inst, Great Falls, MT USA Int Heart Inst, Missoula, MT USA Int Heart Inst Missoula MT USAInt Heart Inst, Missoula, MT USA Benefis Hosp, Dept Pathol, Great Falls, MT USA Benefis Hosp Great Falls MT USA s Hosp, Dept Pathol, Great Falls, MT USA
Titolo Testata:
CORONARY ARTERY DISEASE
fascicolo: 7, volume: 11, anno: 2000,
pagine: 537 - 544
SICI:
0954-6928(200010)11:7<537:AOMAAU>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
LASER REVASCULARIZATION; CORONARY ANGIOGENESIS; VASCULAR ENDOTHELIUM; TIE2 RECEPTOR; CHANNELS; LIGAND; VEGF; DIFFERENTIATION; ANGIOPOIETIN-1; EXPRESSION;
Keywords:
transmyocardial laser revascularization; angiogenesis; mouse; fibroblast growth factor; vascular endothelial cell growth factor; microvascular; myocardium;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Coffin, JD Univ Montana, Dept Pharmaceut Sci, SB 244, Missoula, MT 59812 USA Univ Montana SB 244 Missoula MT USA 59812 issoula, MT 59812 USA
Citazione:
K. Chiotti et al., "Activation of myocardial angiogenesis and upregulation of fibroblast growth factor-2 in transmyocardial-revascularization-treated mice", CORON ART D, 11(7), 2000, pp. 537-544

Abstract

Objective To evaluate the growth factor responses associated with myocardial angiogenesis,Design Mice were treated with transmyocardial revascularization (TMR) and evaluated for angiogenic and growth factor responses. Methods TMR was performed via thoractomy with a 27 g needle. At 2, 5, and 7 days post-treatment, hearts were removed from the TMR treated and controlgroups, then assayed for angiogenesis, fibroblast growth factor (FGF)-2 expression and vascular endothelial cell growth factor (VEGF) expression,Results TMR caused an angiogenic reaction in the myocardial blood vessels at 7 days post-TMR treatment, Elevated FGF-2 corresponded with increased TMR related angiogenesis. VEGF levels only increased in hearts that were prewounded then TMR treated. Conclusions The data show that TMR stimulates myocardial angiogenesis. Theangiogenic reaction is mediated by FGF-2 which increased in most experimental treatment groups, The VEGF response was more specific, requiring prewounding then TMR treatment for a VEGF increase, Coron Artery Dis 11:537-544 (C) 2000 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 23:25:41