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Titolo:
Relationships between blood viscosity and insulin-like growth factor I status in athletes
Autore:
Monnier, JF; Benhaddad, AA; Micallef, JP; Mercier, J; Brun, JF;
Indirizzi:
CHU Lapeyronie, CERAMM, Serv Cent Physiol Clin, F-34295 Montpellier 5, France CHU Lapeyronie Montpellier France 5 Clin, F-34295 Montpellier 5, France CHRU Montpellier, F-34295 Montpellier, France CHRU Montpellier Montpellier France F-34295 F-34295 Montpellier, France
Titolo Testata:
CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
fascicolo: 4, volume: 22, anno: 2000,
pagine: 277 - 286
SICI:
1386-0291(2000)22:4<277:RBBVAI>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL AGGREGATION; HORMONE; EXERCISE; HEMORHEOLOGY; RHEOLOGY; BINDING; ADULTS;
Keywords:
blood viscosity; hemorheology; erythrocyte deformability; erythrocyte aggregability; human; male; exercise training; overtraining; insulin-like growth factor binding protein 1; insulin-like growth factor binding protein 3; insulin-like growth factor I; growth hormone; body fluids; sweating;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Brun, JF CHU Lapeyronie, CERAMM, Serv Cent Physiol Clin, F-34295 Montpellier 5, France CHU Lapeyronie Montpellier France 5 34295 Montpellier 5, France
Citazione:
J.F. Monnier et al., "Relationships between blood viscosity and insulin-like growth factor I status in athletes", CL HEMORH M, 22(4), 2000, pp. 277-286

Abstract

Exercise training is known (1) to enhance the function of the GH-IGF-I system, which has profound effects on body fluid status; (2) to increase bloodfluidity. Thus, we investigated during an exercise-test in 39 male elite sportsmen (age 23.7 +/- 0.72 years; body mass index 23.7 +/- 0.28 kg/m(2)) the possible relationships between GH and IGF-I status and the rheological properties of blood. Two correlations indicate a relationship between body hydration and fitness: isometric handgrip strength is correlated with the percentage of extracellular water in total body water (r = 0.432, p = 0.02) and the aerobic working capacity W-170 is negatively correlated with hematocrit (r = -0.341, p = 0.039). Water loss during exercise appears to be inversely related to fitness as evaluated by W-170 (r = -0.529, p = 0.05), and is positively correlated with the score of signs of overtraining (r = 0.725,p = 0.003) and with the red boood cell aggregation index (r = 0.584, p = 0.036). Finally, while the GH peak value is correlated with the extracellular water volume (r = 0.393, p = 0.02), IGF-I is correlated with blood viscosity (r = 0.546, p = 0.0003), suggesting that when IGF-I values are within the upper quintile (> 340 ng/ml) IGF-I may unfavourably affect blood rheology. Among factors of blood viscosity, IGF-I exhibits a borderline correlation (p = 0.05) with "Tk" and the ratio IGF1/IGFBP3 which reflects free circulating IGF-I is correlated with red cell aggregability measured with the Myrenne "M" (r = 0.485, p = 0.014) and S-60 (r = 0.396, p = 0.494). These findings confirm the importance of hydration and dehydration as determinants ofboth blood rheology and exercise performance. Moreover, they suggest that values of IGF-I within the upper quintile are associated with an impairmentof blood fluidity, possibly due to a direct effect of IGF-I on red cell deformability and aggregability.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 12:33:17