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Titolo:
Anticonvulsants and peripheral nerve function - Results of prospective monitoring in patients with newly diagnosed epilepsy
Autore:
Bogliun, G; Di Viesti, P; Monticelli, ML; Beghi, E; Zarrelli, M; Simone, P; Airoldi, L; Frattola, L;
Indirizzi:
Osped San Gerardo, Ctr Epilessia & Clin Neurol, Monza, Italy Osped San Gerardo Monza Italy Ctr Epilessia & Clin Neurol, Monza, Italy Mario Negri Inst Pharmacol Res, I-20157 Milan, Italy Mario Negri Inst Pharmacol Res Milan Italy I-20157 I-20157 Milan, Italy IRCCS, Osped Casa Sollievo, Div Neurol, San Giovanni Rotondo, Italy IRCCSSan Giovanni Rotondo Italy iv Neurol, San Giovanni Rotondo, Italy IRCCS Don Gnocchi, Milan, Italy IRCCS Don Gnocchi Milan ItalyIRCCS Don Gnocchi, Milan, Italy
Titolo Testata:
CLINICAL DRUG INVESTIGATION
fascicolo: 3, volume: 20, anno: 2000,
pagine: 173 - 180
SICI:
1173-2563(200009)20:3<173:AAPNF->2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHENYTOIN; CARBAMAZEPINE; NEUROPATHY; THERAPY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Beghi, E Mario Negri Inst Pharmacol Res, Via Eritrea 62, I-20157 Milan, Italy Mario Negri Inst Pharmacol Res Via Eritrea 62 Milan Italy I-20157
Citazione:
G. Bogliun et al., "Anticonvulsants and peripheral nerve function - Results of prospective monitoring in patients with newly diagnosed epilepsy", CLIN DRUG I, 20(3), 2000, pp. 173-180

Abstract

Background: Retrospective studies report that long-term use of anticonvulsants correlates with peripheral nerve dysfunction. However, these results are biased by different drug combinations, the use of toxic dosages, and thepresence of other causes of polyneuropathy. Objective: To assess the risk of peripheral nerve impairment in patients known to be free from polyneuropathy who received anticonvulsants as monotherapy at standard daily dosages. Design and Setting: This was a prospective observational study of outpatients seen at two hospital centres in Italy. Patients and Participants: 39 men and 42 women aged 13 to 67 years (mean 30.5 years) with previously untreated epilepsy. Methods: Patients were given monotherapy with valproic acid (sodium valproate) [n = 44] or carbamazepine (n = 37) at standard daily dosages to achieve normal plasma concentrations. Each patient was screened for existing polyneuropathy or risk factors for polyneuropathy before inclusion; they were then assessed for clinical and electrophysiological findings of polyneuropathy at entry and at 6, 12 and 24 months. Results: After 24 months of treatment only one patient had clinical signs of polyneuropathy, and six patients had symptoms of polyneuropathy. The electrophysiological values did not show significant changes or trends. Only one patient had abnormal electrophysiological findings, which were only subclinical, in all the follow-up examinations, and eight patients had abnormalvalues at two subsequent visits. No consistent patterns were found, and data were unaffected when the drugs were examined separately or when patientswere grouped according to whether or not they had symptoms of polyneuropathy. Conclusions: Previously untreated young to middle-aged patients receiving monotherapy with standard daily dosages of valproic acid or carbamazepine are not at risk of developing polyneuropathy within 24 months.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 06:31:24