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Titolo:
EFFECTS OF ADENOSINE AND ADENOSINE-ANALOGS ON MEAN CIRCULATORY FILLING PRESSURE AND CARDIAC-OUTPUT IN ANESTHETIZED RATS
Autore:
TABRIZCHI R;
Indirizzi:
MEM UNIV NEWFOUNDLAND,FAC MED,DIV BASIC MED SCI ST JOHNS NF A1B 3V6 CANADA
Titolo Testata:
Naunyn-Schmiedeberg's archives of pharmacology
fascicolo: 1, volume: 356, anno: 1997,
pagine: 69 - 75
SICI:
0028-1298(1997)356:1<69:EOAAAO>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
SENSITIVE POTASSIUM CHANNELS; CORONARY-ARTERIES; ADENINE-NUCLEOTIDES; ANGIOTENSIN-II; A(3) RECEPTOR; PITHED RAT; AGONISTS; NEUROTRANSMISSION; VASODILATATION; VASOPRESSIN;
Keywords:
MEAN CIRCULATORY FILLING PRESSURE; ADENOSINE RECEPTORS; CARDIAC OUTPUT; VENOUS RESISTANCE; ARTERIAL RESISTANCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
R. Tabrizchi, "EFFECTS OF ADENOSINE AND ADENOSINE-ANALOGS ON MEAN CIRCULATORY FILLING PRESSURE AND CARDIAC-OUTPUT IN ANESTHETIZED RATS", Naunyn-Schmiedeberg's archives of pharmacology, 356(1), 1997, pp. 69-75

Abstract

The effects of adenosine and adenosine analogues, 2-[p-(2-[carboxyethyl) phenethylamino]-5'-N-ethylcarboxamidoadenosine (CGS 21680) and N-6-2-(4-aminophenyl)-ethyladenosine (APNEA), on mean arterial pressure, cardiac output, mean circulatory filling pressure, arterial resistance, venous resistance and heart rate in untreated or treated (with ganglion-blockers mecamylamine and atropine) pentobarbital-anesthetized rats were examined. Infusion of adenosine (100, 300 and 900 mu g/kg/min),CGS 21680 (0.1, 0.3 and 0.9 mu g/kg/min) or APNEA (1.0, 3.0 and 9.0 mu g/kg/min) reduced mean arterial pressure and arterial resistance in all groups. Adenosine and APNEA also reduced mean circulatory filling pressure, venous resistance and heart rate in untreated animals. Furthermore, APNEA but not adenosine reduced cardiac output. In contrast, CGS 21680 increased cardiac output and heart rate but did not have any effect on mean circulatory filling pressure or venous resistance. In ganglion-blocked rats, APNEA reduced cardiac output, mean circulatory filling pressure and heart rate, while adenosine did not have any effect on these parameters. In addition, APNEA and adenosine reduced arterial resistance but were unable to alter venous resistance while CGS 21680 reduced mean circulatory filling pressure and arterial resistance but did not further affect cardiac output, heart rate and venous resistance in ganglion-blocked animals. The results of the present study suggest that adenosine and APNEA dilate arterioles and vein, whereas CGS 21680 causes arterial dilatation but not venodilatation in untreated animals due to hypotension-induced sympathetic activation. A possible explanation for the present observations could be differences in the distribution of vascular A(2) versus A(3) adenosine receptors in the venous circulation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 20:09:18