Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Dendritic spine structural anomalies in fragile-X mental retardation syndrome
Autore:
Irwin, SA; Galvez, R; Greenough, WT;
Indirizzi:
Univ Illinois, Beckman Inst, Urbana, IL 61801 USA Univ Illinois Urbana ILUSA 61801 ois, Beckman Inst, Urbana, IL 61801 USA Univ Illinois, Dept Psychol, Neurosci Program, Urbana, IL 61801 USA Univ Illinois Urbana IL USA 61801 Neurosci Program, Urbana, IL 61801 USA Univ Illinois, Dept Psychol, Med Scholars Programs, Urbana, IL 61801 USA Univ Illinois Urbana IL USA 61801 Scholars Programs, Urbana, IL 61801 USA Univ Illinois, Dept Psychiat, Urbana, IL 61801 USA Univ Illinois Urbana IL USA 61801 is, Dept Psychiat, Urbana, IL 61801 USA Univ Illinois, Dept Cell & Struct Biol, Urbana, IL 61801 USA Univ Illinois Urbana IL USA 61801 ell & Struct Biol, Urbana, IL 61801 USA
Titolo Testata:
CEREBRAL CORTEX
fascicolo: 10, volume: 10, anno: 2000,
pagine: 1038 - 1044
SICI:
1047-3211(200010)10:10<1038:DSSAIF>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; FMR1 KNOCKOUT MICE; RAT VISUAL-CORTEX; DOWNS-SYNDROME; PYRAMIDAL NEURONS; ALCOHOL EXPOSURE; CEREBRAL-CORTEX; STORAGE DISEASE; MESSENGER-RNA; FULL MUTATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
79
Recensione:
Indirizzi per estratti:
Indirizzo: Greenough, WT Univ Illinois, Beckman Inst, 405 N Matthews Ave, Urbana, IL 61801 USA Univ Illinois 405 N Matthews Ave Urbana IL USA 61801 801 USA
Citazione:
S.A. Irwin et al., "Dendritic spine structural anomalies in fragile-X mental retardation syndrome", CEREB CORT, 10(10), 2000, pp. 1038-1044

Abstract

Fragile-X syndrome is the most common single-gene inherited form of mentalretardation. Morphological studies suggest a possible failure of the synapse maturation process. Cerebral cortical spine morphology in fragile-X syndrome and in a knockout mouse model of it appears immature, with long, thin spines much more common than the stubby and mushroom-shaped spines more characteristic of normal development. In human fragile-X syndrome there is also a higher density of spines along dendrites, suggesting a possible failureof synapse elimination. While variously misshapen spines are characteristic of a number of mental retardation syndromes, the overabundance of spines seen in fragile-X syndrome is unusual. Taken with evidence of neurotransmitter activation of the synthesis of the fragile-X protein (FMRP) at synapsesin vitro and evidence for behaviorally induced FMRP expression in vivo, and with evidence compatible with a role for FMRP in regulating the synthesisof other proteins, it is possible that FMRP serves as an 'immediate early protein' at the synapse that orchestrates aspects of synaptic development and plasticity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 02:42:58