Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Serotonin induces EPSCs preferentially in layer V pyramidal neurons of thefrontal cortex in the rat
Autore:
Lambe, EK; Goldman-Rakic, PS; Aghajanian, GK;
Indirizzi:
Yale Univ, Sch Med, Interdept Neurosci Program, Neurobiol Sect, New Haven,CT 06520 USA Yale Univ New Haven CT USA 06520 , Neurobiol Sect, New Haven,CT 06520 USA Yale Univ, Sch Med, Dept Psychiat, New Haven, CT 06520 USA Yale Univ New Haven CT USA 06520 , Dept Psychiat, New Haven, CT 06520 USA Yale Univ, Sch Med, Dept Pharmacol, New Haven, CT 06520 USA Yale Univ NewHaven CT USA 06520 Dept Pharmacol, New Haven, CT 06520 USA
Titolo Testata:
CEREBRAL CORTEX
fascicolo: 10, volume: 10, anno: 2000,
pagine: 974 - 980
SICI:
1047-3211(200010)10:10<974:SIEPIL>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXCITATORY POSTSYNAPTIC CURRENTS; RETROGRADE TRACING TECHNIQUE; RANGE CORTICOFUGAL AXONS; RECEPTOR MESSENGER-RNA; 5-HT2A RECEPTOR; PREFRONTAL CORTEX; LOCUS-COERULEUS; CEREBRAL-CORTEX; AFFERENT-PROJECTIONS; MEDIODORSAL NUCLEUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Lambe, EK Yale Univ, Sch Med, Interdept Neurosci Program, Neurobiol Sect, POB 208074, New Haven, CT 06520 USA Yale Univ POB 208074 New Haven CT USA 06520 Haven, CT 06520 USA
Citazione:
E.K. Lambe et al., "Serotonin induces EPSCs preferentially in layer V pyramidal neurons of thefrontal cortex in the rat", CEREB CORT, 10(10), 2000, pp. 974-980

Abstract

The effect of serotonin (5-HT) on the release of glutamate was examined inpyramidal cells in layers II-VI of the frontal cortex. The intracellular recording electrode contained 1% biocytin so the neurons could later be visualized with an avidin-biotin peroxidase method. Pyramidal cells in layer V of the frontal cortex showed the greatest 5-HT-induced increase in both thefrequency and amplitude of 'spontaneous' (non-electrically evoked) excitatory post-synaptic currents (EPSCs). A small proportion of neurons in layer II/III showed an increase in EPSC frequency, whereas cells in layer VI showed no significant change in either EPSC frequency or amplitude. The physiological response to 5-HT mirrors the high density of 5-HT2A receptors in layer V, as well as the pattern of thalamic projections in frontal cortex. Thespecific induction of EPSCs in layer V neurons suggests that 5-HT preferentially modulates the output neurons of the frontal cortex.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 10:08:28