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Titolo:
Intense noise induces formation of vasoactive lipid peroxidation products in the cochlea
Autore:
Ohinata, Y; Miller, JM; Altschuler, RA; Schacht, J;
Indirizzi:
Univ Michigan, Kresge Hearing Res Inst, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 ng Res Inst, Ann Arbor, MI 48109 USA Osaka Med Coll, Dept Otolaryngol, Osaka 5698686, Japan Osaka Med Coll Osaka Japan 5698686 ept Otolaryngol, Osaka 5698686, Japan
Titolo Testata:
BRAIN RESEARCH
fascicolo: 1-2, volume: 878, anno: 2000,
pagine: 163 - 173
SICI:
0006-8993(20000929)878:1-2<163:INIFOV>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
LASER DOPPLER MEASUREMENTS; INDUCED HEARING-LOSS; PIG INNER-EAR; GUINEA-PIG; BLOOD-FLOW; STIMULATION ALTERS; SUPPORTING CELLS; SOUND EXPOSURE; FREE-RADICALS; IN-VIVO;
Keywords:
reactive oxygen species; noise-induced hearing loss; 8-isoprostane; prostanoids;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Schacht, J Univ Michigan, Kresge Hearing Res Inst, 1301 E Ann St, Ann Arbor, MI 48109USA Univ Michigan 1301 E Ann St Ann Arbor MI USA 48109 MI 48109USA
Citazione:
Y. Ohinata et al., "Intense noise induces formation of vasoactive lipid peroxidation products in the cochlea", BRAIN RES, 878(1-2), 2000, pp. 163-173

Abstract

This study investigates the correlation between the formation of reactive oxygen species (ROS) and auditory damage in noise-induced hearing loss. Thenoise exposure (4-kHz octave band, 115 dB SPL, 5 h) created permanent threshold shifts at frequencies from 2 to 20 kHz. The lipid peroxidation product, 8-isoprostane, was determined biochemically and histochemically as an indicator of ROS. Noise exposure increased 8-isoprostane levels in the cochlea in a time-dependent manner. After 5 h of exposure, 8-isoprostane levels were more than 30-fold greater than baseline, and decreased rapidly after the termination of noise. The immunoreactivity to 8-isoprostane was increasedin the stria vascularis, spiral ganglion cells and the organ of Corti. In the organ of Corti, immunostaining was restricted to the second turn in a region 10-12 mm from the apex. This region sustained most of the permanent hair cell damage as revealed in surface preparations. Outer hair cells were more heavily immunostained than inner hair cells while Hensen's cells showed still less immunostain. These data are consistent with the view that ROS are involved in noise-induced damage. However, the relationship between ROSformation and tissue damage appears complex. In the organ of Corti, the pattern of noise-induced lipid peroxidation correlates well with subsequent morphological damage. The stria vascularis, however, does not sustain permanent damage despite intense lipid peroxidation. Differences in endogenous antioxidant levels and commitment to different apoptotic or survival pathwaysmay underlie such differential responses. (C) 2000 Elsevier Science B.V. All rights reserved.

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Documento generato il 18/09/20 alle ore 17:22:03