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Titolo:
High levels of human herpesvirus 8 viral load, human interleukin-6, interleukin-10, and C reactive protein correlate with exacerbation of multicentric Castleman disease in HIV-infected patients
Autore:
Oksenhendler, E; Carcelain, G; Aoki, Y; Boulanger, E; Maillard, A; Clauvel, JP; Agbalika, F;
Indirizzi:
Hop St Louis, Serv Immunohematol, Dept Immunol & Hematol, Virol Lab, F-75010 Paris, France Hop St Louis Paris France F-75010 atol, Virol Lab, F-75010 Paris, France Hop La Pitie Salpetriere, Immunol Lab, Paris, France Hop La Pitie Salpetriere Paris France riere, Immunol Lab, Paris, France NCI, Med Branch, NIH, Bethesda, MD 20892 USA NCI Bethesda MD USA 20892NCI, Med Branch, NIH, Bethesda, MD 20892 USA
Titolo Testata:
BLOOD
fascicolo: 6, volume: 96, anno: 2000,
pagine: 2069 - 2073
SICI:
0006-4971(20000915)96:6<2069:HLOHH8>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
SARCOMA-ASSOCIATED HERPESVIRUS; ACQUIRED-IMMUNODEFICIENCY-SYNDROME; PRIMARY EFFUSION LYMPHOMA; B-CELL LYMPHOMA; KAPOSIS-SARCOMA; SYSTEMIC MANIFESTATIONS; PERIPHERAL-BLOOD; DNA-SEQUENCES; INVOLVEMENT; EXPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Oksenhendler, E Hop St Louis, Serv Immunohematol, Dept Immunol & Hematol, Virol Lab, 1 AveClaude Vellefaux, F-75010 Paris, France Hop St Louis 1 Ave Claude Vellefaux Paris France F-75010
Citazione:
E. Oksenhendler et al., "High levels of human herpesvirus 8 viral load, human interleukin-6, interleukin-10, and C reactive protein correlate with exacerbation of multicentric Castleman disease in HIV-infected patients", BLOOD, 96(6), 2000, pp. 2069-2073

Abstract

Multicentric Castleman disease (MCD) is a distinct type of lymphoproliferative disorder associated with inflammatory symptoms and interleukin-6 (IL-6) dysregulation. In the context of human immunodeficiency Virus (HIV) infection, MCD is associated with human herpesvirus 8 (HHV8) infection. In a prospective study of 23 HIV-infected patients with MCD, clinical symptoms of MCD were present at 45 visits, whereas patients were in chemotherapy-inducedclinical re mission at 50 visits. Symptoms were associated with a high level of serum C reactive protein, high HHV8 viral load in peripheral blood mononuclear cells, and high plasma human IL-6 and IL-10 levels. Strong correlations between plasma IL-6 and plasma IL-10 with the HHV8 viral load suggest that both cytokines may be involved in the pathogenesis of this virus-associated lymphoproliferative disorder. (Blood. 2000;96:2069-2073) (C) 2000 by The American Society of Hematology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 10:18:46