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Titolo:
Abnormalities of cAMP signaling in affective disorders: implications for pathophysiology and treatment
Autore:
Perez, J; Tardito, D; Mori, S; Racagni, G; Smeraldi, E; Zanardi, R;
Indirizzi:
Univ Milan, Ist Sci H San Raffaele, Dept Neuropsychiat Sci, Sch Med, I-20127 Milan, Italy Univ Milan Milan Italy I-20127 ychiat Sci, Sch Med, I-20127 Milan, Italy Univ Milan, Ctr Neuropharmacol, Inst Pharmacol Sci, Milan, Italy Univ Milan Milan Italy Neuropharmacol, Inst Pharmacol Sci, Milan, Italy
Titolo Testata:
BIPOLAR DISORDERS
fascicolo: 1, volume: 2, anno: 2000,
pagine: 27 - 36
SICI:
1398-5647(200003)2:1<27:AOCSIA>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
BIPOLAR AFFECTIVE-DISORDER; DEPENDENT PROTEIN-KINASE; RAT CEREBRAL-CORTEX; ANTIDEPRESSANT ADMINISTRATION INCREASES; ADENYLYL-CYCLASE ACTIVITY; MESSENGER-RNA EXPRESSION; MOOD-STABILIZING AGENTS; NERVE GROWTH-FACTOR; LONG-TERM BLOCKADE; MAJOR DEPRESSION;
Keywords:
affective disorders; antidepressants; mood stabilizers; phosphoproteins; PKA;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
97
Recensione:
Indirizzi per estratti:
Indirizzo: Perez, J Univ Milan, Ist Sci H San Raffaele, Dept Neuropsychiat Sci, Sch Med, Via Luigi Prinetti 29, I-20127 Milan, Italy Univ Milan Via Luigi Prinetti 29 Milan Italy I-20127 ilan, Italy
Citazione:
J. Perez et al., "Abnormalities of cAMP signaling in affective disorders: implications for pathophysiology and treatment", BIPOL DIS, 2(1), 2000, pp. 27-36

Abstract

Objective: During the last decade, much attention has been given to the role of signal transduction pathways in affective disorders. This review describes the possible role of the cAMP signaling in such disorders. Methods: Among the components of cAMP signaling, this review focuses on the cAMP-dependent phosphorylation system. We analyzed the basic components of the cAMP-dependent phosphorylation system and the preclinical evidence supporting their involvement in the biochemical action of antidepressants andmood stabilizers. The clinical data available until now, concerning the possible link between the cAMP-dependent phosphorylation system and the pathophysiology of affective disorders, are also reviewed. Results: The studies herein presented demonstrated that the levels and theactivity of cAMP-dependent protein kinase are altered by antidepressants and mood stabilizers. Furthermore, these medications are able to modify the phosphorylation state, as well as the levels of some of the cAMP-dependent protein kinase substrates. More recently, clinical studies have reported abnormalities in the cAMP-dependent phosphorylation system in both peripheralcells and the postmortem brain of patients with affective disorders. Conclusions: Overall, these studies support an involvement of cAMP signaling in affective disorders. The precise knowledge of the findings has the potential to improve the understanding of pharmacotherapy and to provide directions for the development of novel biochemical and genetic research strategies on the pathogenesis of affective disorders.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 10:34:12