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Titolo:
Serotonin in mania and in the mechanism of action of mood stabilizers: a review of clinical studies
Autore:
Shiah, IS; Yatham, LN;
Indirizzi:
Univ British Columbia, Dept Psychiat, Div Mood Disorders, Mood Disorders Clin Res Unit, Vancouver, BC V6T 2A1, Canada Univ British Columbia Vancouver BC Canada V6T 2A1 ver, BC V6T 2A1, Canada Natl Def Med Ctr, Tri Serv Gen Hosp, Dept Psychiat, Taipei, Taiwan Natl Def Med Ctr Taipei Taiwan Gen Hosp, Dept Psychiat, Taipei, Taiwan
Titolo Testata:
BIPOLAR DISORDERS
fascicolo: 2, volume: 2, anno: 2000,
pagine: 77 - 92
SICI:
1398-5647(200006)2:2<77:SIMAIT>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAJOR AFFECTIVE-DISORDERS; PLATELET H-3-IMIPRAMINE BINDING; TRICYCLIC-RESISTANT DEPRESSION; POSITRON-EMISSION-TOMOGRAPHY; BIOGENIC-AMINE METABOLITES; ACUTE TRYPTOPHAN DEPLETION; NEURO-ENDOCRINE RESPONSES; LITHIUM-TREATED PATIENTS; SERUM CORTISOL-LEVELS; HEALTHY-HUMAN MALES;
Keywords:
anticonvulsants; bipolar disorder; 5-HT; lithium; mania; mood stabilizers; serotonin;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
186
Recensione:
Indirizzi per estratti:
Indirizzo: Yatham, LN Univ British Columbia, Dept Psychiat, Div Mood Disorders, Mood Disorders Clin Res Unit, 2255 Wesbrook Mall, Vancouver, BC V6T 2A1, Canada Univ British Columbia 2255 Wesbrook Mall Vancouver BC Canada V6T 2A1
Citazione:
I.S. Shiah e L.N. Yatham, "Serotonin in mania and in the mechanism of action of mood stabilizers: a review of clinical studies", BIPOL DIS, 2(2), 2000, pp. 77-92

Abstract

Objectives: Serotonin (5-hydroxytryptamine. 5-HT) was implicated in the pathophysiology of manic-depressive illness as early as 1958. Although extensive evidence has accumulated since then to support 5-HT's role in depression, relatively fewer studies examined its role in mania, The purpose of thispaper was to review and summarize the current state of knowledge on the role of 5-HT in mania and its treatment. Methods: We systemically reviewed clinical studies of 1) 5-HT function in mania and 2) 5-HT in the mechanism of action of mood stabilizers, includinglithium and anticonvulsants. Results: Review showed that cerebrospinal fluid, postmortem, platelet, neuroendocrine challenge, and tryptophan depletion studies provided some evidence to support the hypothesis that a 5-HT deficit is involved in mania and that enhancement of 5-HT neurotransmission exerts a mood-stabilizing effect. Conclusions: There is some evidence from clinical studies for the contribution of 5-HT in mania and in the mechanism of action of mood stabilizers. However, it is very likely that other neurotransmitters also play important roles. Future directions for research include 1) in vivo study of 5-HT receptor subtypes using positron emission tomography, 2) investigation of the interaction between 5-HT and other neurotransmitter systems, and 3) determination of the relationships between diagnostic subtypes of mania and 5-HT function and other neurotransmitter systems.

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Documento generato il 25/01/20 alle ore 09:33:20