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Titolo:
Development of plasmin and plasma kallikrein selective inhibitors and their effect on M1 (Melanoma) and HT29 cell lines
Autore:
Okada, Y; Tsuda, Y; Wanaka, K; Tada, M; Okamoto, U; Okamoto, S; Hijikata-Okunomiya, A; Bokonyi, G; Szende, B; Keri, G;
Indirizzi:
Kobe Gakuin Univ, Fac Pharmaceut Sci, Kobe, Hyogo 6512180, Japan Kobe Gakuin Univ Kobe Hyogo Japan 6512180 Sci, Kobe, Hyogo 6512180, Japan Kobe Gakuin Univ, High Technol Res Ctr, Kobe, Hyogo 6512180, Japan Kobe Gakuin Univ Kobe Hyogo Japan 6512180 Ctr, Kobe, Hyogo 6512180, Japan Kobe Res Projects Thrombosis & Haemostasis, Kobe, Hyogo 6550033, Japan Kobe Res Projects Thrombosis & Haemostasis Kobe Hyogo Japan 6550033 Japan Kobe Univ, Sch Med, Fac Hlth Sci, Kobe, Hyogo 6540142, Japan Kobe Univ Kobe Hyogo Japan 6540142 c Hlth Sci, Kobe, Hyogo 6540142, Japan Semmelweis Univ Med, H-1088 Budapest, Hungary Semmelweis Univ Med Budapest Hungary H-1088 ed, H-1088 Budapest, Hungary
Titolo Testata:
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
fascicolo: 19, volume: 10, anno: 2000,
pagine: 2217 - 2221
SICI:
0960-894X(20001002)10:19<2217:DOPAPK>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTER-DIRECTED PLASMIN; APOPTOSIS; DEATH;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
13
Recensione:
Indirizzi per estratti:
Indirizzo: Okada, Y Kobe Gakuin Univ, Fac Pharmaceut Sci, Kobe, Hyogo 6512180, Japan Kobe Gakuin Univ Kobe Hyogo Japan 6512180 , Hyogo 6512180, Japan
Citazione:
Y. Okada et al., "Development of plasmin and plasma kallikrein selective inhibitors and their effect on M1 (Melanoma) and HT29 cell lines", BIOORG MED, 10(19), 2000, pp. 2217-2221

Abstract

trans-4-Aminomethylcyclohexanecarbonyl-Tyr(O-Pic)-octylamide (YO-2) inhibited plasmin (PL) selectively, while trans-4-aminomethylcyclohexanecarbonyl-Phe-4-carboxymethylanilide (YO-1) inhibited plasma kallikrein (PK). YO-2 induced apoptosis of M1 (melanoma) cell line and HT29 colon carcinoma cells during 24 h through activation of caspase-3, while YO-1 did not affect either cell line even during 48 h. (C) 2000 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/10/20 alle ore 01:07:16