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Titolo:
ASSOCIATION OF THE RENIN GENE POLYMORPHISM WITH ESSENTIAL-HYPERTENSION IN A CHINESE POPULATION
Autore:
CHIANG FT; HSU KL; TSENG CD; LO HM; CHERN TH; TSENG YZ;
Indirizzi:
NATL TAIWAN UNIV HOSP,DEPT INTERNAL MED,1 CHAN TEH ST TAIPEI 10016 TAIWAN NATL TAIWAN UNIV,COLL MED,DEPT INTERNAL MED TAIPEI TAIWAN NATL TAIWAN UNIV,COLL MED,DEPT LAB MED TAIPEI TAIWAN
Titolo Testata:
Clinical genetics
fascicolo: 6, volume: 51, anno: 1997,
pagine: 370 - 374
SICI:
0009-9163(1997)51:6<370:AOTRGP>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
FRAGMENT-LENGTH-POLYMORPHISMS; BLOOD-PRESSURE; LINKAGE; RATS;
Keywords:
GENETICS; HYPERTENSION; POLYMORPHISM; RENIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
F.T. Chiang et al., "ASSOCIATION OF THE RENIN GENE POLYMORPHISM WITH ESSENTIAL-HYPERTENSION IN A CHINESE POPULATION", Clinical genetics, 51(6), 1997, pp. 370-374

Abstract

To study the association of renin gene polymorphism with essential hypertension in the Chinese population, 86 hypertensive and 107 normotensive subjects were enrolled from an epidemiologic survey. Leukocyte DNA was extracted and digested with Hind III and Bgl I restriction enzymes. Southern hybridization was done with digoxigenin-incorporated renin gene probes generated by polymerase chain reaction. The restriction fragments were detected by anti-digoxigenin antibody and enzyme methods. Two Hind III polymorphysms of the renin gene (8.7 kb and 6.2 kb) were identified. The allele frequences were 129(75%) and 43(25%), respectively, in hypertensives; they were 139(65%) and 75(35%), respectively, in normotensives (chi(2)=4.074, p=0.044). The genotypes of 8.7/8.7,8.7/6.2 and 6.2/6.2 were significantly different between hypertensives and normotensives, being 45(52%), 39(45%), 2(3%) and 48(45%), 43(40%),and 16(15%), respectively (chi(2) = 9.002, p = 0.011). The Bgl I polymorphism did not show a difference between hypertensives and normotensives. Thus, we conclude that the renin gene Hind III polymorphysm is associated with hypertension in this Chinese population.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 05:36:59