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Titolo:
Metabolic depression and enhanced O-2 affinity of mitochondria in hypoxic hypometabolism
Autore:
St-Pierre, J; Tattersall, GJ; Boutilier, RG;
Indirizzi:
Univ Cambridge, Dept Zool, Cambridge CB2 3EJ, England Univ Cambridge Cambridge England CB2 3EJ ool, Cambridge CB2 3EJ, England
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
fascicolo: 4, volume: 279, anno: 2000,
pagine: R1205 - R1214
SICI:
0363-6119(200010)279:4<R1205:MDAEOA>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIBERNATING GROUND-SQUIRRELS; LIVER-MITOCHONDRIA; OXIDATIVE-PHOSPHORYLATION; CITELLUS-UNDULATUS; ENERGY-METABOLISM; OXYGEN; RESPIRATION; ADAPTATION; RATS; FROG;
Keywords:
frog; hypoxia; state 3; state 4; P-50;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: St-Pierre, J Univ Cambridge, Dept Zool, Downing St, Cambridge CB2 3EJ, England Univ Cambridge Downing St Cambridge England CB2 3EJ England
Citazione:
J. St-Pierre et al., "Metabolic depression and enhanced O-2 affinity of mitochondria in hypoxic hypometabolism", AM J P-REG, 279(4), 2000, pp. R1205-R1214

Abstract

This study examined whether the steady-state hypometabolism seen in overwintering frogs (Rana temporaria) is reflected at the mitochondrial level either by a reduction in their resting (state 4) and active (state 3) respiration rates and/or by increases in O-2 affinity. We isolated mitochondria from the skeletal muscle of cold-submerged frogs at different stages during their hibernation in normoxic and hypoxic water. A modest metabolic depression at the whole animal level (normoxic submergence) was not associated with a reduction in mitochondrial state 4 and state 3 respiration rates. However, mitochondria isolated from frogs that were submerged for 1 mo manifested an increase in their O-2 affinity compared with controls and with animals submerged for 4 mo. Hypometabolism was more pronounced at the whole animal level during hypoxic submergence and was accompanied by 1) a reduction in mitochondrial state 4 and state 3 rates and 2) an increase in the O-2 affinity of mitochondria. These findings demonstrate that metabolic depression canbe reflected at all levels of biological organization in hypoxia-tolerant animals.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 16:38:02