Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Norepinephrine reuptake, baroreflex dynamics, and arterial pressure variability in rats
Autore:
Bertram, D; Barres, C; Cheng, Y; Julien, C;
Indirizzi:
Fac Pharm Lyon, Dept Physiol & Pharmacol Clin, CNRS, UMR 5014, F-69373 Lyon, France Fac Pharm Lyon Lyon France F-69373 CNRS, UMR 5014, F-69373 Lyon, France Second Mil Med Univ, Dept Pharmacol, Shanghai 200433, Peoples R China Second Mil Med Univ Shanghai Peoples R China 200433 433, Peoples R China
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
fascicolo: 4, volume: 279, anno: 2000,
pagine: R1257 - R1267
SICI:
0363-6119(200010)279:4<R1257:NRBDAA>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYMPATHETIC-NERVE ACTIVITY; BLOOD-PRESSURE; HEART-RATE; SPECTRAL-ANALYSIS; CONSCIOUS RATS; BARORECEPTOR REFLEX; DESIPRAMINE; LABILITY; STIMULATION; RESPONSES;
Keywords:
aortic depressor nerve; desipramine; Mayer waves; spectral analysis; renal sympathetic nerve activity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Bertram, D Fac Pharm Lyon, Dept Physiol & Pharmacol Clin, CNRS, UMR 5014, 8 Av Rockefeller, F-69373 Lyon, France Fac Pharm Lyon 8 Av Rockefeller Lyon France F-69373 on, France
Citazione:
D. Bertram et al., "Norepinephrine reuptake, baroreflex dynamics, and arterial pressure variability in rats", AM J P-REG, 279(4), 2000, pp. R1257-R1267

Abstract

This study examined the effect of norepinephrine reuptake blockade with desipramine (DMI) on the spontaneous variability of the simultaneously recorded arterial pressure (AP) and renal sympathetic nerve activity (SNA) in conscious rats. Acute DMI administration (2 mg/kg iv) depressed AP Mayer waves(similar to 0.4 Hz) and increased low-frequency (<0.2 Hz) components of APvariability. DMI decreased renal SNA variability, especially due to the abolition of oscillations related to Mayer waves. To examine whether DMI-induced changes in AP and renal SNA variabilities could be explained by alterations in the dynamic characteristics of the baroreceptor reflex loop, the frequency responses of mean AP to aortic depressor nerve stimulation were studied in urethan-anesthetized rats. DMI accentuated the low-pass filter properties of the transfer function without significantly altering the fixed time delay. The frequency responses of iliac vascular conductance to stimulation of the lumbar sympathetic chain were studied in an additional group of anesthetized rats. DMI did not markedly alter the low-pass filter properties of the transfer function and slightly increased the fixed time delay. These results suggest that the DMI-induced decrease in the dynamic gain of thebaroreceptor reflex is responsible for the decreased spontaneous renal SNAvariability and the accompanying increased AP variability. The "slowing down" of baroreflex responses cannot be attributed to an effect of DMI at thevascular neuroeffector junction.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/08/20 alle ore 19:47:51