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Titolo:
Prolonged endothelin B receptor blockade causes pulmonary hypertension in the ovine fetus
Autore:
Ivy, DD; Parker, TA; Abman, SH;
Indirizzi:
Childrens Hosp, Dept Cardiol, Denver, CO 80218 USA Childrens Hosp Denver CO USA 80218 sp, Dept Cardiol, Denver, CO 80218 USA Univ Colorado, Sch Med, Pediat Heart Lung Ctr, Cardiol Sect, Denver, CO 80218 USA Univ Colorado Denver CO USA 80218 Ctr, Cardiol Sect, Denver, CO 80218 USA Univ Colorado, Sch Med, Pediat Heart Lung Ctr, Sect Neonatol, Denver, CO 80218 USA Univ Colorado Denver CO USA 80218 tr, Sect Neonatol, Denver, CO 80218 USA Univ Colorado, Sch Med, Pediat Heart Lung Ctr, Sect Pulm Med, Denver, CO 80218 USA Univ Colorado Denver CO USA 80218 tr, Sect Pulm Med, Denver, CO 80218 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
fascicolo: 4, volume: 279, anno: 2000,
pagine: L758 - L765
SICI:
1040-0605(200010)279:4<L758:PEBRBC>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONGENITAL HEART-DISEASE; VASCULAR SMOOTH-MUSCLE; FETAL LAMBS; IMMUNOREACTIVE ENDOTHELIN-1; DUCTUS-ARTERIOSUS; NEWBORN-INFANT; BLOOD-FLOW; CIRCULATION; BIRTH; RESPONSES;
Keywords:
nitric oxide; persistent pulmonary hypertension of the newborn; congenital heart disease; pulmonary circulation; BQ-788;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Ivy, DD Childrens Hosp, Dept Cardiol, Box B100,1056 E 19th Ave, Denver, CO80218 USA Childrens Hosp Box B100,1056 E 19th Ave Denver CO USA 80218 18 USA
Citazione:
D.D. Ivy et al., "Prolonged endothelin B receptor blockade causes pulmonary hypertension in the ovine fetus", AM J P-LUNG, 279(4), 2000, pp. L758-L765

Abstract

Endothelin (ET)-1 contributes to regulation of pulmonary vascular tone andstructure in the normal ovine fetus and in models of perinatal pulmonary hypertension. The hemodynamic effects of ET-1 are due to activation of its receptors. The ETA receptor mediates vasoconstriction and smooth muscle cellproliferation, whereas the ETB receptor mediates vasodilation. In a lamb model of chronic intrauterine pulmonary hypertension, ETB receptor activity and gene expression are decreased. To determine whether prolonged ETB receptor blockade causes pulmonary hypertension, we studied the hemodynamic effects of selective ETB receptor blockade with BQ-788. Animals were treated with an infusion of either BQ-788 or vehicle for 7 days. Prolonged BQ-788 treatment increased pulmonary arterial pressure and pulmonary vascular resistance (P < 0.05). The pulmonary vasodilator response to sarafotoxin 6c, a selective ETB receptor agonist, was attenuated after 7 days of BQ-788 treatment, demonstrating pharmacological blockade of the ETB receptor. Animals treated with BQ-788 had greater right ventricular hypertrophy and muscularization of small pulmonary arteries (P < 0.05). Lung ET-1 levels were threefold higher in the animals treated with BQ-788 (P < 0.05). We conclude that prolonged selective ETB receptor blockade causes severe pulmonary hypertension and pulmonary vascular remodeling in the late-gestation ovine fetus.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 08:40:22