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Titolo:
Prior exercise training increases collateral-dependent blood flow in rats after acute femoral artery occlusion
Autore:
Yang, HT; Laughlin, MH; Terjung, RL;
Indirizzi:
Univ Missouri, Coll Vet Med, Columbia, MO 65211 USA Univ Missouri Columbia MO USA 65211 Coll Vet Med, Columbia, MO 65211 USA Univ Missouri, Coll Med, Columbia, MO 65211 USA Univ Missouri Columbia MOUSA 65211 uri, Coll Med, Columbia, MO 65211 USA Univ Missouri, Dalton Cardiovasc Res Ctr, Columbia, MO 65211 USA Univ Missouri Columbia MO USA 65211 ovasc Res Ctr, Columbia, MO 65211 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
fascicolo: 4, volume: 279, anno: 2000,
pagine: H1890 - H1897
SICI:
0363-6135(200010)279:4<H1890:PETICB>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
SKELETAL-MUSCLE ARTERIOLES; NITRIC-OXIDE SYNTHASE; PROSTACYCLIN PRODUCTION; MEDIATED DILATION; ENDOTHELIAL-CELLS; ADAPTATIONS; GROWTH; ANGIOGENESIS; EXPRESSION; RESPONSES;
Keywords:
vascular adaptations; peripheral arterial insufficiency; microspheres; acute-onset vascular occlusion;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Terjung, RL Univ Missouri, Coll Vet Med, E102 Vet Med Bldg, Columbia, MO 65211 USA Univ Missouri E102 Vet Med Bldg Columbia MO USA 65211 5211 USA
Citazione:
H.T. Yang et al., "Prior exercise training increases collateral-dependent blood flow in rats after acute femoral artery occlusion", AM J P-HEAR, 279(4), 2000, pp. H1890-H1897

Abstract

We evaluated whether prior training would improve collateral blood flow (BF) to the calf muscles after acute-onset occlusion of the femoral artery. Exercise training was performed in the absence of any vascular occlusion. Adult male Sprague-Dawley rats (similar to 325 g) were kept sedentary (n = 14), limited to cage activity, or exercise trained (n = 14) for 6 wk by treadmill running. Early in the day of measurement, animals were surgically prepared for BF determination, and the femoral arteries were occluded bilaterally. Four to five hours later, collateral BF was determined twice during treadmill running with the use of Ce-141 and Sr-85 microspheres: first, at a demanding speed and, second, after a brief rest and at a higher speed. The absence of any further increase in BF at the higher speed indicated that maximal collateral BF was measured. Prior training increased calf muscle BF bysimilar to 70% compared with sedentary animals; however, absolute BF remained below values previously observed in animals with a well-developed collateral vascular tree. Thus prior training appeared to optimize the use of the existing collateral circuit. This implies that altered vasoresponsivenessinduced in normal nonoccluded vessels with exercise training serves to improve collateral BF to the periphery.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 11:48:39