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Titolo:
Protease gene analysis of HIV type 1 non-B subtypes in Spain
Autore:
Holguin, A; Rodes, B; Soriano, V;
Indirizzi:
Hosp Carlos III, Infect Dis Serv, Inst Salud Carlos III, Madrid 28010, Spain Hosp Carlos III Madrid Spain 28010 Salud Carlos III, Madrid 28010, Spain
Titolo Testata:
AIDS RESEARCH AND HUMAN RETROVIRUSES
fascicolo: 14, volume: 16, anno: 2000,
pagine: 1395 - 1403
SICI:
0889-2229(200009)16:14<1395:PGAOHT>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNODEFICIENCY-VIRUS TYPE-1; HETERODUPLEX MOBILITY ASSAY; VACCINE EVALUATION SITES; COMMERCIAL METHODS; BRANCHED-DNA; IN-VIVO; GROUP-O; PLASMA; RNA; IDENTIFICATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Soriano, V Hosp Carlos III, Infect Dis Serv, Inst Salud Carlos III, C Rafael Calvo 7 2 A, Madrid 28010, Spain Hosp Carlos III C Rafael Calvo 7 2 A Madrid Spain 28010 Spain
Citazione:
A. Holguin et al., "Protease gene analysis of HIV type 1 non-B subtypes in Spain", AIDS RES H, 16(14), 2000, pp. 1395-1403

Abstract

The protease gene of human immunodeficiency virus type 1 (HIV-1) clinical isolates found in 15 immigrants (most of African origin) living in Spain was examined. Phylogenetic analyses were performed, taking as reference a panel of 26 HIV protease gene sequences deposited with GenBank. All specimens belonged to four distinct HIV-1 non-B subtypes: C (three cases), F (one), G(nine), and H (two). Five patients harboring subtype G strains were further classified within the IbNg recombinant clade. A high degree of genetic polymorphism at the protease gene was seen in all subtypes. Moreover, changesat positions associated with drug resistance were seen in subtype G viruses carried by patients who had not been exposed to protease inhibitors. Plasma viremia was lower than expected for some samples, according to the clinical features and the CD4(+) cell count, suggesting that viral load titers were underestimated by all three commercially available techniques. This work represents the first genetic characterization of subtypes C, F, G, and H in Spain.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 12:37:14