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Titolo:
Strauss (1969) revisited: a psychosis continuum in the general population?
Autore:
van Os, J; Hanssen, M; Bijl, RV; Ravelli, A;
Indirizzi:
Univ Limburg, European Grad Neurosci, Dept Psychiat & Neuropsychol, NL-6200 MD Maastricht, Netherlands Univ Limburg Maastricht Netherlands NL-6200 MD D Maastricht, Netherlands Netherlands Inst Mental Hlth & Addict, Trimbos Inst, NL-3500 AS Utrecht, Netherlands Netherlands Inst Mental Hlth & Addict Utrecht Netherlands NL-3500 AS nds
Titolo Testata:
SCHIZOPHRENIA RESEARCH
fascicolo: 1-2, volume: 45, anno: 2000,
pagine: 11 - 20
SICI:
0920-9964(20000929)45:1-2<11:S(RAPC>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTERNATIONAL DIAGNOSTIC INTERVIEW; LATENT CLASS ANALYSIS; MENTAL-HEALTH SURVEY; ROSCOMMON FAMILY; RISK-FACTORS; SCHIZOPHRENIA; DISORDER; NETHERLANDS; PREVALENCE; SCHIZOTYPY;
Keywords:
continuum; genetics; phenotype; psychosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: van Os, J Univ Limburg, European Grad Neurosci, Dept Psychiat & Neuropsychol, POB 616, NL-6200 MD Maastricht, Netherlands Univ Limburg POB 616 Maastricht Netherlands NL-6200 MD herlands
Citazione:
J. van Os et al., "Strauss (1969) revisited: a psychosis continuum in the general population?", SCHIZOPHR R, 45(1-2), 2000, pp. 11-20

Abstract

Although dichotomously defined for clinical purposes, psychosis may exist as a continuous phenotype in nature. A random sample of 7076 men and women aged 18-64 years were interviewed by trained lay interviewers with the Composite International Diagnostic Interview (CIDI). Those with evidence of psychosis according to the CIDI were additionally interviewed by psychiatrists. For the 17 CIDI core psychosis items, we compared a psychiatrist's ratingof hallucinations and/or delusions (Clinical Psychosis; sample;prevalence 4.2%) with three other possible positive CIDI ratings of the same items: (i) symptom present, but not clinically relevant (NCR Symptom; sample prevalence 12.9%); (ii) symptom present, but the result of drugs or somatic disorder (Secondary Symptom; sample prevalence 0.6%); (iii) symptom appears present, but there is a plausible explanation (Plausible Symptom; sample prevalence 4.0%). Of the 1237 individuals with any type of positive psychosis rating (sample prevalence 17.5%), only 26 (2.1%) had a DSM-III-R diagnosis of non-affective psychosis. All the different types of psychosis ratings were strongly associated with the presence of psychiatrist-rated Clinical Psychosis (NCR Symptom: OR=3.4; 95% CI: 2.9-3.9; Secondary Symptom: OR=4.5; 95% CI: 2.7-7.7; Plausible Symptom: OR=5.8; 95% CI: 4.7-7.1). Associations with lower age, single marital status, urban dwelling, lower level of education, lower quality of life, depressive symptoms and blunting of affect did not differ qualitatively as a function of type of rating of the psychotic symptom, were similar in individuals with and without any CIDI lifetime diagnosis, and closely resembled those previously reported for schizophrenia. Presence of any rating of hallucinations was strongly associated with any rating of delusions (OR = 6.7; 95% CI: 5.6-8.1), regardless of presence of any CIDI lifetime diagnosis. The observation by Strauss (1969. Hallucinations and delusions as points on continua function. Arch. Gen. Psychiatry 21, 581-586) that dichotomously diagnosed psychotic symptoms in clinical samples are, in fact, part of a continuum of experiences, may also apply to the general population. The boundaries of the psychosis phenotype may extend beyond theclinical concept of schizophrenia. (C) 2000 Elsevier Science B.V. All rights reserved.

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Documento generato il 02/12/20 alle ore 14:12:16